The Origin and Development of Neutrophils

  • Patrick Murphy


The information under this general heading is of three rather disconnected kinds. First, there is the classic morphological work, which traces the origin of blood neutrophils from myeloblasts in bone marrow, and physiological evidence about functional differences between mature and immature cells. Second, there is evidence about the kinetics of neutrophil production and utilization during normal and pathological states, which has been derived mostly from radioactively labeled populations of cells. Third, there are the attempts to find a more fundamental cellular origin for the neutrophil and other blood cells. We will take them up in this order.


Bone Marrow Bone Marrow Cell Mitotic Index Normal Bone Marrow Tritiated Thymidine 
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Selected Reading

  1. LoBue, J., Stem cell and neutrophilic granulocyte kinetics, Med. Clin. North Am. 57:265 (1973).PubMedGoogle Scholar
  2. Metcalf, D., and Moore, M. A. S., Haemopoietic Cells, American Elsevier Publishing Co., New York, 1971.Google Scholar
  3. Haemopoietic Stem Cells, Ciba Foundation Symposium 13 (new series), Associated Scientific Publishers, Amsterdam, 1973.Google Scholar


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Copyright information

© Plenum Publishing Corporation 1976

Authors and Affiliations

  • Patrick Murphy
    • 1
  1. 1.The Johns Hopkins University School of MedicineBaltimoreUSA

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