Protein Disposition in Biological Membranes
The history of concepts of the molecular structure of biological membranes can be divided into four phases. The first phase (~1925 to ~ 1963) saw the development and general acceptance of a membrane model in which the body of the membrane was composed of a continuous bimolecular leaflet of phospholipid. The outer surfaces of the bilayer were polar and were coated with protein held by electrostatic forces. The second or “Phospholipid Revolution” phase (~1963 to ~ 1968) questioned the basis for the concept of the phospholipid bimolecular leaflet and sought to replace this model with one in which a discontinuous phase of nestling lipoprotein subunits made up the body of the membrane. The second phase ended with the accumulation of evidence from a variety of new powerful physical methods which gave strong support for the bimolecular leaflet and extended the evidence for this structure to a variety of cell membranes. The third phase therefore marked a return to phase one insofar as the phospholipid configuration of biological membranes was concerned.
KeywordsErythrocyte Membrane Biological Membrane Polar Head Group Human Erythrocyte Membrane Submitochondrial Particle
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