Biomembranes pp 81-145 | Cite as

The Membron: A Functional Hypothesis for the Translational Regulation of Genetic Expression

  • Thomas K. Shires
  • Henry C. Pitot
  • Stuart A. Kauffmann
Part of the Biomembranes book series (B, volume 5)


Although the operon concept advanced by Jacob and Monod (1961) argued that all regulation of genetic expression should be at the transcriptional level, a quantity of evidence has now accumulated, from both microbial systems and higher organisms, demonstrating that the amount of enzyme present in a cell or tissue may be controlled at the translational level. As seen by Berman (1967a,b), such control may occur at several levels, including post-transcriptional or “prepolysomal,” which involves the temporal and spatial interval separating mRNA synthesis and its incorporation into the polysome; the “polysomal” level wherein decodement of mRNA is directly regulated; and “postpolysomal” level which may include the phenomenon of dynamic turnover or degradation of specific protein molecules in vivo.


Rough Endoplasmic Reticulum Cyclic Permutation Translational Regulation Messenger Ribonucleic Acid Free Polysome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • Thomas K. Shires
    • 1
  • Henry C. Pitot
    • 1
  • Stuart A. Kauffmann
    • 2
  1. 1.McArdle Laboratory, Departments of Oncology and PathologyUniversity of Wisconsin Medical SchoolMadisonUSA
  2. 2.Department of Theoretical BiologyUniversity of ChicagoChicagoUSA

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