Age, Sex, Circadian and Seasonal Variations in the Hemostatic Mechanism

  • Derek Ogston


Platelets have been found in embryos of eleven weeks’ gestational age (Bleyer et al., 1971) while clumps of platelets, suggesting their ability to aggregate, were seen by 12 to 15 weeks. Platelets aggregate in response to ADP by the 19th week, but less strongly than adult platelets (Pandolfi et al., 1972): no response to epinephrine or collagen was seen. The number of platelets in the blood at 30 weeks’ gestation was reported to be close to adult levels (Kalpaktsoglou and Emery, 1965).


Factor VIII Fibrinolytic Activity Fibrinolytic System Adult Level Factor Xiii Deficiency 
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© Derek Ogston 1983

Authors and Affiliations

  • Derek Ogston
    • 1
  1. 1.University of AberdeenUK

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