Hormonal Influences on the Hemostatic Mechanism

  • Derek Ogston


A variety of observations have pointed to possible hormonal influences on the physiological control of platelet function, coagulation and fibrinolysis. In addition, there are some tantalising data available to suggest that the fibrinolytic system may be involved in the modulation of hormone production or action. This chapter reviews some of the available information on the relationships between hormones and hemostatic function and components. At the present time definitive conclusions on these associations are lacking. This arises in part from the complex interrelationships between the various endocrine glands which militates against precise interpretations of the influence of individual hormones on hemostasis. It can be readily appreciated that the differentiation of the changes which result from direct induction of synthesis, release or inhibition of hemostatic factors by a single hormone from those which are secondary to the effect of the hormone on other tissues or organs, including other endocrine glands, may be extremely difficult. A further problem in interpretation is that the majority of reported studies have examined changes in components of the hemostatic mechanism after the administration of large and unphysiological quantities of hormone, or have measured such components in patients with clinical syndromes resulting from gross hormonal deficiency or excess.


Plasminogen Activator Factor VIII Fibrinolytic Activity Hormonal Influence Factor Viii Level 
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Copyright information

© Derek Ogston 1983

Authors and Affiliations

  • Derek Ogston
    • 1
  1. 1.University of AberdeenUK

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