Skip to main content

Hemostasis and the Menstrual Cycle

  • Chapter
  • 88 Accesses

Abstract

The separate consideration of hemostasis in relation to the menstrual cycle is pertinent for three reasons. Firstly, any alterations in hemostatic components through the cycle must be considered in studies on women in their reproductive years. Secondly, the changes may provide information on the influence of hormonal changes on the hemostatic mechanism. Thirdly, the periodic shedding of the endometrium offers a unique physiological challenge to the hemostatic system.

Keywords

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bell, W.D. (1913–14) ‘The causes of the non-coagulability of normal menstrual blood and of pathological clotting’, Journal of Pathology and Bacteriology, 18,462–7

    Article  Google Scholar 

  • Beller, F.K. (1971) ‘Observations on the clotting of menstrual blood clot formation’, American Journal of Obstetrics and Gynecology, 111,535–43

    Google Scholar 

  • Beller, F.K. and Weiss, G. (1966) ‘The fibrinolytic enzyme system in cervical mucus’, Fertility and Sterility, 17,654–62

    Google Scholar 

  • Beller, F.K., Goebelsmann, U., Douglas, G.W. and Johnson, A. (1964) ‘The fibrinolytic system during the menstrual cycle’, Obstetrics and Gynecology, 23,12–6

    Google Scholar 

  • Brakman, P., Albrechtsen, O.K. and Astrup, T. (1966) ‘A comparative study of coagulation and fibrinolysis in blood from normal men and women’, British Journal of Haematology, 12,74–85

    Article  Google Scholar 

  • Caspary, E.A. and Peberdy, M. (1965) ‘Oral contraception and blood-platelet adhesiveness’’, Lancet, i,1142–1143

    Article  Google Scholar 

  • Christiaens, G.C.M.L., Sixma, J.J. and Haspels, A.A. (1980) ‘Morphology of haemostasis in menstrual endometrium’, British Journal of Obstetrics and Gynaecology, 87,425–39

    Article  Google Scholar 

  • Christiaens, G.C.M.L., Sixma, J.J. and Haspels, A.A. (1981) ‘Fibrin and platelets in menstrual discharge before and after the insertion of an intrauterine contraceptive device’, American Journal of Obstetrics and Gynecology. 140,793–8

    Google Scholar 

  • Egeberg, O. and Owren, P.A. (1963) ‘Oral contraception and blood coagulability’, British Medical Journal, 1,220–1

    Article  Google Scholar 

  • Genell, S. (1936) ‘A study of variations in the number of blood-platelets during the menstrual cycle’, Journal of Obstetrics and Gynaecology of the British Empire, 43,1124–34

    Google Scholar 

  • Hahn, L. (1974) ‘On fibrinolysis and coagulation during parturition and menstruation’, Acta Obstetricia et Gynaecologica Scandinavica,Suppl. 28

    Google Scholar 

  • Jespersen, J. and Kluft, C. (1982) ‘Histidine-rich glycoprotein and plasminogen levels in plasma during the normal menstrual cycle and in women on oral contraceptives low in estrogen’, Haemostasis, 11,Suppl. 1, 49

    Google Scholar 

  • Kullander, S. and Källen, B. (1961) ‘The fibrinolytic activity of human endometrium, studied in tissue culture’, Acta Obstetricia et Gynaecologica Scandinavica, 40,1–15

    Article  Google Scholar 

  • Marx, R. and Rovatti, B. (1952) ‘Untersuchung über das Vethalten der Fibrinolyse in Serum während des Menstrualcyklus’, Haematologica, 36,685–92

    Google Scholar 

  • McBride, J.A. and Snodgrass, C.A. (1968) ‘The effect of the normal menstrual cycle on the total platelet count, adhesive platelet count and platelet adhesiveness’, Journal of Obstetrics and Gynaecology of the British Commonwealth, 75,357–9

    Article  Google Scholar 

  • Menon, I.S. (1968) ‘Fibrinolytic activity in the blood of 99 healthy young British, African and Asian subjects’, Laboratory Practice, 17,194–5

    Google Scholar 

  • Möbius, G. and Johannes, S. (1963) ‘Variations in the thrombocyte count during the female genital cycle’, Zentralblatt fur Gynaekologie, 85,489–500

    Google Scholar 

  • Page, E.W., Glendenning, M.B. and Parkinson, D. (1957) ‘Cyclic biochemical changes in the human endometrium. With special reference to the fibrinolytic enzyme’, American Journal of Obstetrics and Gynecology, 62,1100–5

    Google Scholar 

  • Pepper, H. and Lindsay, S. (1956) ‘Elevation of platelets in mid-cycle: an indication of ovulation’, Science, 124,180–1

    Article  Google Scholar 

  • Pepper, H. and Lindsay, S. (1959) ‘Levels of platelets, eosinophils, total leucocytes and polymorphonuclear leucocytes during the normal menstrual cycle’, Obstetrics and Gynecology, 14,657–64

    Google Scholar 

  • Pepper, H. and Lindsay, S. (1960) ‘Levels of eosinophils, platelets, leukocytes and 17-hydroxycorticosteroids during normal menstrual cycle’, Proceedings of the Society for Experimental Biology and Medicine, 104,145–7

    Google Scholar 

  • Pohle, F.J. (1939) ‘The blood platelet count in relation to the menstrual cycle in normal women’, American Journal of Medical Sciences, 197,40–7

    Article  Google Scholar 

  • Rao, A.R. (1964) ‘Plasma fibrinolytic activity and menstrual cycle in women’, Lancet, ii,593–4

    Article  Google Scholar 

  • Rybo, G. (1966) ‘Plasminogen activators in the endometrium. II. Clinical aspects’, Acta Obstetricia et Gynaecologica Scandinavica, 45,429–50

    Article  Google Scholar 

  • Sheppard, B.L., Dockeray, C.J. and Bonnar, J. (1982) ‘The fibrin component of menstrual blood’, Haemostasis, 11,Suppl. 1, 98

    Google Scholar 

  • Smith, O.W. and Smith, G.V.S. (1945) ‘Fibrinolytic enzyme in menstruation and late pregnancy’, Science, 102,135–7

    Article  Google Scholar 

  • Teger-Nilsson, A.-C. (1979) ‘Use of chromogenic substrates for screening of inhibitors of coagulation and fibrinolysis in patients’, in M.F. Scully and V.V. Kakkar (eds.), Chromogenic Peptide Substrates: Chemistry and Clinical Usage,Churchill Livingstone, Edinburgh, pp. 269–76

    Google Scholar 

  • Tindall, H., Zuzal, M., Paton, R.C. and McNicol, G.P. (1981) ‘Changes in thrombin-stimulated platelet malondialdehyde production during the menstrual cycle’, Journal of Clinical Pathology, 34,595–8

    Article  Google Scholar 

  • Turksoy, R.N., Phillips, L.L. and Southam, A.L. (1961) ‘Influence of ovarian function on the fibrinolytic enzyme system. I. Ovulatory and anovulatory cycles’, American Journal of Obstetrics and Gynecology, 82,1311–5

    Google Scholar 

  • Whitehouse, H.B. (1914) ‘The physiology and pathology of uterine haemorrhage’, Lancet, i,877–885

    Google Scholar 

  • Willson, J.R. and Munnell, E.R. (1946) ‘Fibrinolytic activity in blood serum during pregnancy complicated by hypertensive toxaemias’, Proceedings of the Society for Experimental Biology and Medicine, 62,277–9

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Derek Ogston

About this chapter

Cite this chapter

Ogston, D. (1983). Hemostasis and the Menstrual Cycle. In: The Physiology of Hemostasis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7319-3_13

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-7319-3_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7321-6

  • Online ISBN: 978-1-4684-7319-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics