An Outline of the Hemostatic Mechanism

  • Derek Ogston


The term hemostasis refers to the processes involved in the arrest of bleeding following injury. These processes involve the participation of the vessel wall, blood platelets, the coagulation system and, in a less defined way, the fibrinolytic enzyme system. The complexity of the detail of the individual phases of the hemostatic mechanism has the hazard of obscuring its overall pattern and sequence of reactions. This brief introductory summary of the hemostatic processes is intended to provide a general framework for readers with limited previous knowledge in this area of physiology into which can be fitted the more detailed descriptions of its component stages in later chapters.


Coagulation System Coagulation Factor Viii High Molecular Weight Kininogen Activate Clotting Factor Platelet Plug 
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  1. Sanders, A.G. (1970) ‘In vivo observations on haemostasis in the hamster’, in R.G. Macfarlane (ed.), The Haemostatic Mechanism in Man and Other Animals,Academic Press, London, pp. 109–20Google Scholar
  2. Sixma, J.J. (1981) ‘Role of blood vessel, platelet and coagulation interactions in haemostasis’, in A.L. Bloom, D.P. Thomas (eds.), Haemostasis and Thrombosis, Churchill Livingstone, Edinburgh, pp. 253–57Google Scholar
  3. Sixma, J.J. and Wester, J. (1977) ‘The haemostatic plug’, Seminars in Hematology, 14, 265–99Google Scholar

Copyright information

© Derek Ogston 1983

Authors and Affiliations

  • Derek Ogston
    • 1
  1. 1.University of AberdeenUK

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