The Use of Optical Fibers in Biomedical Sensing

  • A. G. Mignani
  • A. M. Scheggi
Part of the NATO ASI Series book series (NSSB, volume 252)


The use of optical fibers in biomedical instrumentation goes back to the 1960s, when thousands of thin glass fibers were successfully assembled in flexible bundles, for imaging hidden areas of the human body. Some fibroscopes were further provided with an ancillary channel, so as to make possible power-laser cavitational-surgery and therapy using large-core optical fibers as a delivery system. In addition to this fiber-based instrumentation, attention has also been given to sensors for monitoring biological functions by means of optical fibers.


Fiber Optic Bundle Stainless Steel Capillary Light Intensity Modulation Fiberoptic Sensor Glass Microcapillary 
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  1. 1.
    J. I. Peterson and G. G. Vurek, “Fiber-optic Sensors for Biomedical Applications”, Science 224, 123–127 (1984)ADSCrossRefGoogle Scholar
  2. 2.
    A. M. Scheggi, “Optical Fibres Sensing in Medicine”, Int. J. Opt. Sens. 1(1), 5–25 (1986)Google Scholar
  3. 3.
    F. P. Milanovich, T. B. Hirschfeld, F. T. Wang, S. M. Klainer and D. Walt, “Clinical Measurements Using Fiber Optics and Optrodes”, Proc. SPIE 494, 18–24 (1984)Google Scholar
  4. 4.
    R. J. Volz and D. A. Christensen, “A Neonatal Fiberoptic Probe for Oximetry and Dye Curves”, IEEE Trans. Biom. Eng. BME-26(7), 416–421 (1979)CrossRefGoogle Scholar
  5. 5.
    A. W. Domanski, S. Kostrzewa and T. R. Wolinski, “Fiber-optic Absorptive Oximeter”, Proc. SPIE 1085, 450–456 (1988)Google Scholar
  6. 6.
    H. Nishihara, J. Koyama, N. Hoki, F. Kajiya, M. Hironaga and M. Kano, “Optical-fiber Laser Doppler Velocimeter for High-resolution Measurement of Pulsatile Blood Flows”, Appl. Opt. 21(10), 1785–1790 (1982)ADSCrossRefGoogle Scholar
  7. 7.
    M. J. Sepaniak, B. J. Tromberg and J. F. Eastham, “Optical Fiber Fluoroprobes in Clinical Analysis”, Clin. Chem. 29(9), 1678–1682 (1983)Google Scholar
  8. 8.
    P. R. King, J. B.Dawson, I. Driver, D. J. Ellis and J. W. Feather, “Design of a Fibre Optic Probe for the In-Vivo Determination of Photosensitizing Drugs”, Proc. SPIE 798, 214–217 (1987)Google Scholar
  9. 9.
    R. Falciai, F. Baldini, G. Conforti, F. Cosi and A. M. Scheggi, “A fiber Optic System for the Detextion of Entero-Gastric Reflux”, Proc. SPIE 990, 18–21 (1988)Google Scholar
  10. 10.
    D. A. Christensen, “Fiberoptic Temperature Sensing for Biomedical Applications”, Proc. SPIE 906, 108–113 (1988)Google Scholar
  11. 11.
    T. C. Rozzel, C. C. Johnson, C. H. Durney, J. L. Lords and R. G. Olsen, “A Nonperturbing Temperature Sensor for Measurements in Electro-magnetic Fields”, J. Microw Power, 9(3), 241–249 (1974)Google Scholar
  12. 12.
    D. De Rossi, A. Benassi, A. L’Abbate and P. Dario, “A new Fibre-Optic Liquid Crystal Catheter for Oxygen Saturation and Blood Flow Measurements in the Coronary Sinus”, J. Biom. Eng. 2(10), 257–264 (1980)CrossRefGoogle Scholar
  13. 13.
    A. M. Scheggi, M. Bacci, M. Brenci, G. Conforti, R. Falciai and A. G. Mignani, “Thermometry by Optical Fibers and a Thermochromic Transducer”, Opt. Eng. 26(6), 534–537 (1987)Google Scholar
  14. 14.
    G. Conforti, M. Brenci, A. Mencaglia and A. G. Mignani, “Fiber-Optic Thermometric Probe Utilizing GRIN Lenses”, Appl. Opt. 28(3), 577–580 (1989)ADSCrossRefGoogle Scholar
  15. 15.
    G. Conforti, M. Brenci, A. Mencaglia, A. G. Mignani and A. M. Scheggi, “Multiplexed Fiber Optic Thermometer”, Proc. SPIE 985, 125–129 (1989)Google Scholar
  16. 16.
    K. A. Wickersheim, “A new Fiberoptic Thermometry System for Use in Medical Hyperthermia”, Proc. SPIE 713, 150–157 (1987)Google Scholar
  17. 17.
    C. Ovrén, M. Sdolfsson and B. Hök, “Fiber-Optic Systems for Temperature and Vibration Measurements in Industrial Applications”, Proc. Int. Conf. Optical Techniques in Process Control (The Hague, June 14–16, 1983), 6781 (1983)Google Scholar
  18. 18.
    R. Kist, S. Drope and H. Wolfelschneider, “Fiber Fabry-Perot (FFP) Thermometer for Medical Applications”, Proc. 2nd International Conference on Optical Fiber Sensors, OFS-2, Stuttgart September 5–7, 1984, 165170 (1984)Google Scholar
  19. 19.
    H. Wolfelschneider, R. Kist, J. Schneider and H. Modler, “A Fiber Fabry Perot Mobility Sensor for the Measurement of Peristaltic Motions in the Upper Gastrointestinal Tract”, Proc. 5th International Conference on Optical Fiber Sensors, OFS-5, New Orleans January 27–29, 1988), 357–360 (1988)Google Scholar
  20. 20.
    T. E. Hansen, “A Fiberoptic Micro-Tip Pressure Transducer for Medical Applications”, Sensors and Actuators 4, 545–554 (1983)CrossRefGoogle Scholar
  21. 21.
    H. Matsumoto, M. Saegusa, K. Saito and K. Mizoi, “The Development of a Fibre Optic Catheter Tip Pressure Transducer”, J. Med. Eng. Tech. 2(5), 239–242, (1978)CrossRefGoogle Scholar
  22. 22.
    C. M. Lawson and V. J. Tekippe, “Fiber-Optic Diaphragm-Curvature Pressure Transducer”, Opt. Lett. 8(5), 286–288 (1983)ADSCrossRefGoogle Scholar
  23. 23.
    P. Dario, D. Fermi and F. Vivaldi, “Fiber-Optic Catheter-Tip Sensor Based on the Photoelastic Effect”, Sensors and Actuators, 12, 35–47 (1987)CrossRefGoogle Scholar
  24. 24.
    G. G. Vurek, “In Vivo Optical Chemical Sensors”, Proc. SPIE 494, 2–6 (1984)Google Scholar
  25. 25.
    A. J. Guthrie, R. Narayanaswamy and D. A. Russel, “Optical Fibres in Chemical Sensing: a Review”, Trans. Inst. M. C. 9(2), 71–80 (1987)CrossRefGoogle Scholar
  26. 26.
    A. M. Scheggi and G. Conforti, “Review: Optical Fibre Sensors and Applications with Particular Reference to Chemical Sensing”, Proc. SPIE 949, 146151 (1988)Google Scholar
  27. 27.
    R. Narayanaswamy and F. Sevilla, “Optical Fibre Sensors for Chemical Species”, J. Phys. E: Scien. Instrum. 21, 10–17 (1988)ADSCrossRefGoogle Scholar
  28. 28.
    J. I. Peterson, S. R. Goldstein and R. V. Fitzgerald, “Fiber Optic pH Probe for Physiological Use”, Anal. Chem. 52(6), 864–869 (1980)CrossRefGoogle Scholar
  29. 29.
    M. Bacci, F. Baldini, F. Cosi, G. Conforti and A. M. Scheggi, “Probe Performance Optimization for pH Continuous Monitoring”, Proc. 6th International Conference on Optical Fiber Sensors, OFS-6, Paris September 1820 1989 ), 425–430 (1989)Google Scholar
  30. 30.
    J. L. Gehrich, D. W. Lubbers, N. Opitz, D. R. Hansmann, W. W. Miller, J. K. Tusa and M. Yafuso, “Optical Fluorescence and its Application to an Intravascular Blood Gas Monitoring System”, IEEE Trans. Biom. Eng. BME-33(2), 117–132 (1986)CrossRefGoogle Scholar
  31. 31.
    J. Tusa, T. Hacker, D. R. Hansmann, T. M. Kaput and T. P. Maxwell, “Fiber Optic Microsensor for Continuous In-Vivo Measurement of Blood Gases” proc. SPIE 713, 137–143 (1986)Google Scholar
  32. 32.
    J. W. Parker and M. E. Cox, “Glucose/Oxygen Sensor”, Proc. SPIE 713, 113–120 (1986)Google Scholar
  33. 33.
    M. Brenci, G. Conforti, R. Falciai, A. G. Mignani and A. M. Scheggi, “All-Fibre Temperature Sensor”, Int. J. Opt. Sens. 1(2), 163–169 (1986)Google Scholar
  34. 34.
    M. Brenci, G. Conforti, R. Falciai, A. G. Mignani and G. Gironi, “Assembling Technique of Microcapsules for Optical Fibre Sensors”, Int. J. Opt. Sens. 2(5), 357–362 (1987)Google Scholar
  35. 35.
    D. M. Jordan, D. R. Walt and F. P. Milanovich, “Physiological pH Fiber Optic Chemical Sensor Based on Energy Transfer”, Anal. Chem. 59 (3), 437439 (1987)CrossRefGoogle Scholar
  36. 36.
    J. D. Andrade, R. A. Vanwagenen, D. E. Gregonis, K. Newby and J. N. Lin, “Remote Fiber-Optic Biosensors Based on Evanescent-excited Fluoro-immunoassay: Concepts and Progress”, IEEE Trans. Electron. Dev. ED-32, 1175–1179 (1985)CrossRefGoogle Scholar
  37. 37.
    J. D. Montgomery, “Fiber Optic Sensor Long-Range Market Forecast”, Proc. SPIE 586, 2–13 (1985)Google Scholar
  38. 38.
    P. McGeehin, “Current Impact of Fibre Optic Sensors”, Proc. SPIE 798, 16–23 (1987)Google Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • A. G. Mignani
    • 1
  • A. M. Scheggi
    • 1
  1. 1.IROE - CNRFirenzeItaly

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