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A Comparison of Laser and Arc-Lamp Spectroscopic Systems for In-Vivo Pharmacokinetic Measurements of Photosensitizers Used in Photodynamic Therapy

  • D. A. Russell
  • P. Nadeau
  • R. H. Pottier
  • G. Jori
  • E. Reddi
Part of the NATO ASI Series book series (NSSB, volume 252)

Abstract

The treatment of neoplastic tissue using photodynamic therapy is currently undergoing a worldwide concerted research effort, enabling human treatment of such tissue using the drug hematoporphyrin derivative (HPD), see for example1. Current research is centered on the development of new photosensitizers, new instrumentation for delivering the required radiant energy, an understanding of processes involved in the selective biodistribution of photosensitizers as well as the mechanism by which the induced cytotoxic reaction is produced.

Keywords

Photodynamic Therapy Nitrogen Laser Rescence Intensity Scopic System Spectroscopic System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    “Photosensitizing Compounds: Their Chemistry, Biology and Clinical use”, Ciba Foundation Symposium 146, Wiley, Chichester (1989)Google Scholar
  2. 2.
    E. Reddi, G. Lo Castro, R. Biolo and G. Jori, “Pharmacokinetic studies with zinc (Il)-phtalocyanine in tumor bearing mice”, Br. J. Cancer, 56:597 (1987)CrossRefGoogle Scholar
  3. 3.
    R. M. Pottier, Y. F. A. Chan, J.-P. LaPlante, T. G. Truscott, J. C. Kennedy and L. A. Beiner, “Non-invasive technique for obtaining fluorescence excitation and emission spectra in-vivo”, Photochem. Photobiol., 44:679 (1986)CrossRefGoogle Scholar
  4. R. M. Pottier and J. C. Kennedy, “Photodiode array fluorescence technique for measuring drug clearance rates in-vivo, J. Photochem. Photobiol., B3:135 (1989).Google Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • D. A. Russell
    • 1
  • P. Nadeau
    • 1
  • R. H. Pottier
    • 1
  • G. Jori
    • 2
  • E. Reddi
    • 2
  1. 1.The Royal Military CollegeKingstonCanada
  2. 2.University of PadovaItaly

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