Endoscopic Photodynamic Therapy: Clinical Aspects

  • P. Spinelli
  • M. Dal Fante
  • A. Mancini
Part of the NATO ASI Series book series (NSSB, volume 252)

Abstract

Photodynamic therapy (PDT) is a selective, experimental treatment for solid tumors. PDT consists of the activation of a photosensitizing agent by light. The photodynamic reaction induced by light causes damage to the tissue containing the photosensitizer in the presence of oxygen.

Keywords

Adenoma Shrinkage Coherence Oncol Porphyrin 

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References

  1. 1.
    H. Tappenier and A. Jesionek, “Therapeutische Versuche mit fluoreszierenden Stoffe”, Münch. Med. Wochenschr. 1:2042 (1903)Google Scholar
  2. 2.
    A. Policard, “Etudes sur les aspects offerts par des tumeurs expérimentales examinées à la lumière de Woods”, Cr. Soc. Biol. 91:1423 (1924)Google Scholar
  3. 3.
    H. Auler and G. Banzer, “Untersuchungen über die Rolle der Porphine bei geschwulstkranken Menschen und Tieren”, Z. Krebforsch. 53:65 (1942)CrossRefGoogle Scholar
  4. 4.
    R. L. Lipson, E. J. Baldes, “The photodynamic properties of a particular hematoporphyrin derivative”, Arch. Dermatol. 82:508 (1960)CrossRefGoogle Scholar
  5. 5.
    R. L. Lipson, E. J. Balder and A. M. Olsen, “Hematoporphyrin derivative: a new aid for endoscopic detection of malignant disease”, J. Thorac. Cardiovasc. Surg. 42:623 (1961)Google Scholar
  6. 6.
    J. Moan, “Porphyrin-sensitized photodynamic inactivation of cells: a review”, Lasers Med. Sci. 1:5 (1986)CrossRefGoogle Scholar
  7. 7.
    R. Hilf, D. B. Smail, R. S. Murant, et al., “Hematoporphyrin derivative-induced photosensitivity of mitochondrial succinate dehydrogenase and selected cytosolic enzymes of R3230 AC mammary adenocarcinomas of rats”, Cancer Res. 44:1483 (1984)Google Scholar
  8. 8.
    C. J. Gomer, “DNA damage and repair in CHO cells following hematoporphyrin photoradiation”, Cancer Lett. 11:161 (1980)ADSCrossRefGoogle Scholar
  9. 9.
    J. Dougherty, “Photodynamic therapy (PDT) of malignant tumors”, CRC Crit. Rev. Oncol/Haemat. 2:83 (1985)CrossRefGoogle Scholar
  10. 10.
    T. J. Dougherty, W. R. Potter and K. R. Weishaupt, “The structure of the active component of hematoporphyrin derivative”, In “Porphyrin Localization and Treatment of Tumors (D. R. Doiron and C. J. Gomer, eds.), Alan R. Liss, Inc., New York, 301 (1984)Google Scholar
  11. 11.
    G. Jori, “Pharmacokinetics studies with hematoporphyrin in tumor-bearing mice”, in “Photodynamic Therapy of Tumors and other Diseases”, G. Jori, C. Perria eds., Progetto Publ., Padova, 159 (1985)Google Scholar
  12. 12.
    D. Mew, C. K. Wat, G. H. N. Towers and J. G. Levy, “Photoimmunotherapy: treatment of animal tumors with tumor specific monoclonal antibody-hematoporphyrin conjugates”, J. Immunol. 130:1473 (1983)Google Scholar
  13. 13.
    R. Kol, E. Ben-Hur, E. Riklis, R. Marko and I. Rosenthal, “Photosensitized inhibition of mitogenic stimulation of human lymphocytes by aluminium phtalocyanine tetrasulphonate”, Las. Med. Sci. 1:187 (1986)CrossRefGoogle Scholar
  14. 14.
    A. M. Richter, E. Sternberg, E. Waterfield, D. Dolphin and J. C. Levy, “Characterization of benzoporphyrin derivative, a new photosen-sitizer”, Proc. SPIE 997:132 (1988)Google Scholar
  15. 15.
    T. J. Dougherty, J. E. Kaufman, A. Goldfarb, K. R. Weishaupt, D. G. Boyle and A. Mittleman, “Photoradiation therapy for the treatment of malignant tumors”, Cancer Res. 38:2628 (1978)Google Scholar
  16. 16.
    P. Spinelli and M. Dal Fante, “Photodynamic therapy” In G. I. tract”, Acta Endosc. 15:69 (1985)Google Scholar
  17. 17.
    J. A. Parrish, “Photomedicine potential for lasers. An overview from lasers in photomedicine and photobiology”, R. Pratesi and C. A. Sacchi eds., Springer, Berlin, 2 (1980)Google Scholar
  18. 18.
    A. L. McKenzie and J. A. S. Carruth, “A comparison of gold-vapour and dye lasers for PDT”, Laser Med. Sci. 1:117 (1986)CrossRefGoogle Scholar
  19. 19.
    T. J. Dougherty, “Photodynamic therapy - New approaches”, Sem. Surg. Oncol. 5:6 (1989)CrossRefGoogle Scholar
  20. 20.
    R. Brancato, L. Giovannoni, R. Pratesi and U. Vanni, “New lasers for ophtalmology: retinal photocoagulation with pulsed diode lasers”, Proc. SPIE 701:365 (1986)Google Scholar
  21. 21.
    P. Spinelli and M. Dal Fante, “Contact laser endoscopic surgery with sapphire microprobes”, Proc. SPIE 701:331 (1986)Google Scholar
  22. 22.
    V. Russo, “Optical fiber delivery systems for laser medical applications” in “Photodynamic Therapy of Tumors and other Diseases”, G. Jori, C. Perria eds., Progetto Publ. Padova, 371 (1985)Google Scholar
  23. 23.
    Y. Hayata, H. Kato, C. Konaka, J. Ono and N. Takizawa, “Hematoporphyrin-derivative and laser photoradiation in the treatment of lung cancer”, Chest 81:269 (1981)CrossRefGoogle Scholar
  24. 24.
    P. Spinelli and M. Dal Fante, “PDT - State of the art”, in “Laser Opto electronics in Medicine”, W. Waidelich and P. Kiefhaber eds., Springer Verlag, 609 (1987)Google Scholar
  25. 25.
    P. Spinelli, S. Andreola, R. Marchesini, E. Melloni, V. Mirabile, P. Pizzetti and F. Zunino, “Endoscopic HpD-laser photoradiation therapy (PRT) of cancer”, In “Porphyrins in Tumor Phototherapy”, A. An-dreoni, R. Cubeddu eds., Plenum Publishing Corporation, 423 (1984)Google Scholar
  26. 26.
    J. T. Allardice, A. C. Rowland, N. S. Williams and C. P. Swain, “A new light delivery system for the treatment of obstructing gastrointestinal cancers by photodynamic therapy”, Gastrointest. Endosc. 35:548 (1989)CrossRefGoogle Scholar
  27. 27.
    Japanese Study for Gastroenterological Endoscopy. Cited by T. Murakami, “Pathomorphological diagnosis, definition and gross classification of early gastric cancer”, T. Murakami ed., Tokyo, University of Tokyo Press (1971)Google Scholar
  28. 28.
    M. Dal Fante, G. Bottiroli and P. Spinelli, “Behaviour of haematoporphyrin derivative in adenomas and adenocarcinomas of the colon: a microfluorometric study”, Lasers Med. Sci. 3:165 (1988)CrossRefGoogle Scholar
  29. 29.
    R. M. Cothren, R. Richards-Kortum, M. V. Sivak, Jr., et al., “Gastrointestinal tissue diagnosis by laser-induced fluorescence spectroscopy at endoscopy”, Gastrointest. Endosc, 128 (1990)Google Scholar
  30. 30.
    E. M. H. Mathus-Vliegen and G. N. J. Tytgat, “Nd:YAG laser photocoagulation in colorectal adenoma. Evaluation of its safety, usefulness, and efficacy”, Gastroenterol. 90:1865 (1986)Google Scholar
  31. 31.
    H. Kato, C. Konaka, J. Ono, et al. “Preoperative laser photodynamic therapy in combination with operation in lung cancer”, J. Thorac. Cardiovasc. Surg. 90:420 (1985)Google Scholar
  32. 32.
    R. C. Benson, Jr., “Laser photodynamic therapy for bladder cancer”, Mayo Clin. Proc. 61:859 (1986)Google Scholar
  33. 33.
    D. Jocham, G. Staehler, C. Caussy, et al., “Integral dye-laser irradiation of photosensitized bladder tumors with the aid of a light-scattering medium”, Prog. Clin. Biol. Res. 170:249 (1984)Google Scholar
  34. 34.
    H. Tajiri, N. Daizukono, S. N. Joffe and Y. Oguro, “Photoradiation therapy in early gastrointestinal cancer”, Gastrointest. Endosc. 33:88 (1987)CrossRefGoogle Scholar
  35. 35.
    J. S. McCaughan, T. E. Williams and B. H. Bethel, “Palliation of esophageal malignancy with photodynamic therapy”, Am. Thor. Surg. 40:113 (1985)CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • P. Spinelli
    • 1
  • M. Dal Fante
    • 1
  • A. Mancini
    • 1
  1. 1.Endoscopic DepartmentNational Cancer InstituteMilanItaly

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