Characterisation and Regulation of UDP-Glucuronosyltransferases

  • Brian Burchell
Part of the NATO ASI Series Advanced Science Institutes Series book series (NSSA, volume 202)


Many drugs, xenobiotics and endogenous compounds are metabolised via common two stage pathway, which was designated as phase 1 (oxidative metabolism) and phase II (conjugation) by Williams (1). Glucuronidation reactions catalysed by the UDP-glucuronosyltransferases (UDPGTs) is arguably the major conjugation system of phase II metabolism. The metabolism of phenacetin, in the example illustrated below (Fig 1), proceeds via oxidative dealkylation to produce paracetamol, a reactive and potentially toxic metabolite. Paracetamol is then rapidly glucuronidated to form a harmless water soluble metabolite which is excreted via the kidneys and urine.


DEAE Cellulose Lithocholic Acid Ammonium Sulphate Fractionation Glucuronidation Reaction Hepatic Endoplasmic Reticulum 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Brian Burchell
    • 1
  1. 1.Department of Biochemical Medicine Ninewells Hospital and Medical SchoolThe University DundeeScotland

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