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Role of the Well-Known Basic and the Recently Discovered Acidic Glutathione S-Transferases in the Control of Genotoxic Metabolites

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Book cover Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds

Part of the book series: NATO ASI Series Advanced Science Institutes Series ((NSSA,volume 202))

Abstract

Glutathione S-transferases (GSTs; E.C. 2. 5. 1. 18) are a family of enzymes which have increasingly attracted the interest of toxicologists, pharmacologists, biochemists and clinicians since their discovery in 1961 (1). Initially, GSTs were believed to serve as intracellular transport proteins for endogenous compounds with limited solubility in water, thus acting as an intracellular equivalent to albumin in blood plasma. In this assumed capacity of reversible binding and transport of various ligands, the corresponding protein was named ligandin (2). Following the discovery of abundant GST occurrence in most forms of aerobic life including plants, and the GST-catalysed conjugation of a wide variety of elec-trophilic substrates with glutathione, GSTs are now generally considered to play a crucial role in the detoxification of foreign compounds such as mutagens, carcinogens and other noxious chemicals (for reviews see Refs. 3–6) by conjugation to glutathione. In addition, GSTs are believed to provide cellular protection by covalent binding of reactive electrophiles to the enzyme, which results in immobilization and inactivation of the compound in question.

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Authors and Affiliations

  1. Institute of Toxicology, University of Mainz Obere Zahlbacher Strasse 67, D-6500, Mainz, Germany

    Franz Oesch, Ingolf Gath, Takashi Igarashi, Hansruedi Glatt & Helmut Thomas

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  1. Franz Oesch
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  2. Ingolf Gath
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  3. Takashi Igarashi
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  4. Hansruedi Glatt
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  5. Helmut Thomas
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Editors and Affiliations

  1. Middle East Technical University, Ankara, Turkey

    Emel Arinç

  2. University of Connecticut Health Center, Farmington, Connecticut, USA

    John B. Schenkman

  3. North Carolina State University, Raleigh, North Carolina, USA

    Ernest Hodgson

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© 1991 Plenum Press, New York

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Oesch, F., Gath, I., Igarashi, T., Glatt, H., Thomas, H. (1991). Role of the Well-Known Basic and the Recently Discovered Acidic Glutathione S-Transferases in the Control of Genotoxic Metabolites. In: Arinç, E., Schenkman, J.B., Hodgson, E. (eds) Molecular Aspects of Monooxygenases and Bioactivation of Toxic Compounds. NATO ASI Series Advanced Science Institutes Series, vol 202. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7284-4_26

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  • DOI: https://doi.org/10.1007/978-1-4684-7284-4_26

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7286-8

  • Online ISBN: 978-1-4684-7284-4

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