Epoxide Hydrolase Isoenzymes and their Individual Contribution to the Control of Toxic Metabolites

  • Franz Oesch
  • Ludwig Schladt
  • Michael Knehr
  • Johannes Döhmer
  • Helmut Thomas
Part of the NATO ASI Series Advanced Science Institutes Series book series (NSSA, volume 202)


Epoxides are highly strained three membered cyclic ethers which are formed in vivo by the microsomal cytochrome P450 dependent monooxygenases as intermediates of several important biosynthetic pathways (leukotriene A4, squalene 2, 3-oxide) and as metabolites of numerous xenobiotic compounds containing olefinic or aromatic double bonds. Further transformation of these epoxides may occur by either, rearrangement to phenols, aliphatic aldehydes, or ketones; by cytochrome P450 dependent reduction to the parent compound; or by spontaneous or enzymatic conjugation to gluta-thione. Epoxides may also bind covalently to cellular nucleophiles, such as proteins and nucleic acids thus eliciting carcinogenic, mutagenic and other toxic effects.


Polycyclic Aromatic Hydrocarbon Epoxide Hydrolase Styrene Oxide Hyperplastic Nodule Microsomal Epoxide Hydrolase 


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Franz Oesch
    • 1
  • Ludwig Schladt
    • 1
  • Michael Knehr
    • 1
  • Johannes Döhmer
    • 1
  • Helmut Thomas
    • 1
  1. 1.Institute of ToxicologyUniversity of Mainz Obere Zahlbacher Straße 67MainzGermany

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