Effects of Inhibitors on the P450-Dependent Metabolism of Endogenous Compounds in Fungi, Protozoa, Plants and Vertebrates

  • Hugo Vanden Bossche
  • Patrick Marichal
  • Gustaaf Willensens
  • Paul A. J. Janssen
Part of the NATO ASI Series Advanced Science Institutes Series book series (NSSA, volume 202)


A great number of the present antifungal agents belong to the class of nitrogen heterocycle derivatives. Examples are the pyrimidine antifungals, triarimol, fenarimol and nuarimol, the Pyridine derivative, buthiobate, the imidazoles, miconazole, clotrimazole, econazole, imazalil, tioconazole, bifonazole, sulconazole and ketoconazole and finally the triazole antifungals, azaconazole, propiconazole, terconazole, fluconazole, itraconazole and saperconazole. All these antifungal agents have been shown to inhibit ergosterol synthesis (the main sterol in most yeasts and fungi) by interacting with the cytochrome P450-dependent 14ß-demethylation (P45014DM) of lanosterol in e.g. Saccharomyces cerevisiae or of 24-methylenedihydrolanosterol in most fungal cells (for reviews see refs. 1–4).


Heme Iron Imidazole Derivative Sterol Biosynthesis Sterol Synthesis Azole Antifungal 


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Hugo Vanden Bossche
    • 1
  • Patrick Marichal
    • 1
  • Gustaaf Willensens
    • 1
  • Paul A. J. Janssen
    • 1
  1. 1.Janssen Research FoundationBeerseBelgium

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