Prostanoid Metabolism and Biologically Active Product Formation
This presentation was designed to introduce the reader to the field of prostanoid metabolism by cytochrome P450 monooxygenases. Therefore, the description of the biosynthesis of prostanoids carried out by cyclooxygenase (not a P450 enzyme) was kept brief. To do justice to the subject of P450 catalyzed metabolism of prostanoids would require an extensive review of the subject which is not the goal of this manuscript. Thus, this presentation intends to concentrate on the metabolism of prostaglandins primarily in the liver. However certain studies on prostaglandin metabolism by monooxygenases in extrahepatic tissues which might provide useful comparison with liver findings, as well as relevance to in vivo situations are also described. Since the presentation of metabolic studies in extrahepatic tissues was not intended to be exhaustive, I apologize to those investigators whose work has been omitted or inadequately covered in this presentation. Studies on cytochrome P450 catalyzed hydroxylation of arachidonic acid have been omitted. A comprehensive review of this subject has been recently published. Additionally the interested reader should consult original publications on arachidonic acid metabolism by Drs. Jorge Capdevila (Nashville, TN, USA), Michal Schwartzman (Valhalla, NY, USA) and Ernst Oliw (Stockholm, Sweden).
KeywordsSeminal Vesicle Liver Microsome Rabbit Liver Extrahepatic Tissue Lung Microsome
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