Xenobiotic Regulation of Cytochrome P-450 Gene Expression

  • Mikael Gillner
  • Jan Bergman
  • Jan-Åke Gustafsson
Part of the NATO ASI Series Advanced Science Institutes Series book series (NSSA, volume 202)


The relative amounts of some of the cytochrome P-450 enzymes are known to be selectively increased by chemicals (Conney, 1982, Whit lock, 1986). Especially interesting is the induction of certain forms of cytochrome P-450 by 5,6-benzof lavone (BNF), polycyclic aromatic hydrocarbons (PAH) such as 3-methylcholanthrene, and chloroaromatics like 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD), since this induction profoundly influences the metabolism of PAH to ultimate carcinogens that are able to form specific adducts with DNA (Conney, 1982). TCDD is the most potent inducer of these particular forms of cytochrome P-450 (c. f. Poland and Knutson, 1982).


Polycyclic Aromatic Hydrocarbon Retinoic Acid Silicone Rubber Thyroid Hormone Receptor Steroid Hormone Action 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Mikael Gillner
    • 1
  • Jan Bergman
    • 2
  • Jan-Åke Gustafsson
    • 1
  1. 1.Department of Medical Nutrition, Karolinska InstituteHuddinge University Hospital, F60Novum, HuddingeSweden
  2. 2.Department of Organic ChemistryRoyal Institute of TechnologyStockholmSweden

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