In Vivo Correlates of In Vitro Studies of Axonal Guidance: Retinal Transplantation in the Mammalian Retinotectal System
It is nearly 100 years since Ramón y Cajal first described the bulbous ends of immature axons (see Ramón y Cajal, 1937), and 80 years since Harrison (1910) provided convincing evidence that these structures were, indeed, growth cones. In the intervening time, a great deal of interest has been directed towards elucidating the mechanisms by which axons are first guided along their pathway of outgrowth to their target regions, and then are matched with appropriate sets of neurons to form functional synaptic circuits.
KeywordsGrowth Cone Retinal Ganglion Cell Superior Colliculus Optic Tectum Glia Limitans
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