In Vivo and In Vitro Guidance of Axons
The brain of a vertebrate contains in one cubic millimeter about 105 neurones, 109 times more than this in the number of synapses, and about a kilometre in the length of axons and dendrites. The neurones, axons, dendrites and synapses are arranged and connected in a highly specific and ordered manner, though relatively little is known about how this complicated system develops. Developing connections between neurones are established via the neuronal growth cone, which has to navigate through an environment crowded with cellular and extra-cellular signals. The growth cone is a structure exquisitely designed for motility and this environmental exploration; it possesses a dynamic cytoskeleton and surface molecules essential for its recognition of, and recognition by, target cells.
KeywordsGrowth Cone Tectal Membrane Commissural Axon Growth Cone Collapse Retinal Axon
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- Bandtlow, C., Zachleder, T., and Schwab, M.E. 1989, Rapid and permanent inhibition of growth cone motility by oligodendrocytes, Neuron, (submitted).Google Scholar
- Cox, T., Mueller, B., Bonhoeffer, F., 1989, Axonal guidance in the chick visual system: Posterior tectal membranes induce collapse of growth cones from the temporal lobe, (submitted).Google Scholar
- Gierer, A. 1987, Directional cues for growing axons forming the retinotectal projection, Development., 101:479.Google Scholar
- Rabacchi, S. A., Nere, R. L., and Dräger, U. C., 1988, Molecular cloning of the “dorsal eye antigen”: Homology to the high affinity laminin receptor, Soc. Neurosci. Abst., 14:769.Google Scholar
- Rager, G.H., 1980, Development of the retinotectal projection in the chicken, in: “Advances in Anatomy, Embryology and Cell Biology”, vol. 63, Brodai, A., van Luisbough, J., Ortmann, R. and Tondury, G., eds., Springer-Verlag, Berlin, p.1.Google Scholar
- Raper, J.A., and Kapfhammer, J.P., 1989, The enrichment of a neuronal growth cone collapsing activity from embryonic brain. Submitted.Google Scholar
- Walter, J., Mueller, B., and Bonhoeffer, F., 1989, Axonal guidance by an avoidance mechanism, J. Physiol. (Paris), in press.Google Scholar
- Yoon, M. G., 1973, Retention of the original topographic polarity by the 180 degree rotated tectal reimplant in young adult goldfish. J. Physiol. (Lond), 233:575.Google Scholar