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Design of Nucleoside Analogs as Potential Antiviral Agents

  • Roland K. Robins
  • Ganapathi R. Revankar
Part of the NATO ASI Series book series (NSSA, volume 143)

Abstract

Viruses are composed of either RNA or DNA, encased in protein shells and often further wrapped in lipid-containing envelopes. Viruses multiply only within living cells, commandeering the host cell to synthesize viral proteins and viral nucleic acids followed by final assembly into new virion particles. Viral infection may vary in severity from mild and transitory infections to illnesses that terminate in death. Persistent viral infection, which for years may not be accompanied by symptoms, can eventually cause chronic degenerative diseases with fatal outcome. It is known that viruses cause certain cancers in animals and man. Successful treatment of viral diseases with antiviral agents requires interruption of virus multiplication by specific inhibition of viral enzymes.

Keywords

Human Immunodeficiency Virus Thymidine Kinase Newcastle Disease Virus Nucleoside Analog Antiviral Agent 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Roland K. Robins
    • 1
  • Ganapathi R. Revankar
    • 1
  1. 1.Nucleic Acid Research InstituteCosta MesaUSA

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