Transient Hypercalciuria During Acute Pyelonephritis and Active Stone Formation
In 1939 Flocks1 reported that “apparently a slight or intermittent obstruction…… in the urinary tract, such as the presence of a small stone in the kidney pelvis, was associated with a significantly higher calcium concentration in the urine from that kidney”, Hennemann et al2 suggested that urinary tract infection might cause hypercalciuria through an impairment of the tubular reabsorption of calcium. These hypotheses have never been tested and idiopathic hypercalciuria is currently regarded as being due to increased absorption of calcium from the gut and/or reduced tubular reabsorption of calcium of unknown cause3. This paper describes a patient who manifested transient renal hypercalciuria concomitantly with episodes of urinary tract infection and multiple stone formation. This association suggests that pyelonephritis and/or partial urinary obstruction due to stone growth may play a role in the genesis of hypercalciuria.
KeywordsCalcium Oxalate Ureteral Stone Tubular Reabsorption Acute Pyelonephritis Urinary Calcium Excretion
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