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Urinary Citrate Excretion in Normals and Patients with Idiopathic Calcium Urolithiasis

  • D. H. Hosking
  • J. W. L. Wilson
  • R. R. Liedke
  • L. H. Smith
  • D. M. Wilson

Abstract

In urine, citrate forms soluble complexes with calcium thereby decreasing the calcium ion activity and, secondarily, the relative supersaturation of both calcium oxalate and calcium phosphate1. In addition, citrate exerts an inhibitory effect on both hydroxy-apatite2 and calcium oxalate crystal growth although the contribution to the latter is minor. The mean urinary citrate excretion in patients with idiopathic calcium urolithiasis has been found to be significantly lower than in control groups4−7 prompting the speculation that hypocitraturia may be an etiologic factor. There are few reports, however, on what constitutes an abnormally low urinary excretion of citrate7,8.

Keywords

Urinary Excretion Calcium Oxalate Stone Disease Urinary Citrate Relative Supersaturation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    A. B. Hastings, F. C. McLean, L. Eichelberger, J. L. Hall, and E. Da Costa, J. Biol. Chem. 107:351 (1934).Google Scholar
  2. 2.
    L. H. Smith, J. L. Meyer, and J. T. McCall, in: “Urinary Calculi”, L. Cifuentes Delatte, A. Rapado, A. Hodgkinson, eds., Karger, Basel (1973).Google Scholar
  3. 3.
    J. L. Meyer and L. H. Smith, Invest. Urol. 13:36 (1975).PubMedGoogle Scholar
  4. 4.
    S. G. Welshman and M. G. McGeown, Br. J. Urol. 48:7 (1976).PubMedCrossRefGoogle Scholar
  5. 5.
    P. O. Schwüle, D. Scholz, M. Paulus, W. Engelhardt, and A. Sigel, Invest. Urol. 16:457 (1979).Google Scholar
  6. 6.
    D. Rudman, M. H. Kutner, S. C. Redd II, W. C. Waters IV, G. G. Gerron, and J. Bleier, J. Clin. Endocrinol. Metab. 55:1052 (1982).PubMedCrossRefGoogle Scholar
  7. 7.
    M. J. Nicar, C. Skurla, K. Sakhaee, and C. Y. C. Pak, Urology 21:8 (1983).PubMedCrossRefGoogle Scholar
  8. 8.
    A. Hodgkinson, Clin. Sci. 23:203 (1962).PubMedGoogle Scholar
  9. 9.
    L. H. Smith, Urol. Clin. N. Am. 1:241 (1974).Google Scholar
  10. 10.
    O. Wrong and H. E. F. Davies, Quart. J. Med. 28:259 (1959).PubMedGoogle Scholar
  11. 11.
    U. Backman, B. G. Danielson, G. Johansson, S. J. Ljunghall, and B. Wikström, Nephron 25:96 (1980).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • D. H. Hosking
    • 1
    • 2
  • J. W. L. Wilson
    • 1
    • 2
  • R. R. Liedke
    • 1
    • 2
  • L. H. Smith
    • 1
    • 2
  • D. M. Wilson
    • 1
    • 2
  1. 1.University of Manitoba, Winnipeg, Queens UniversityKingstonCanada
  2. 2.Mayo ClinicRochester MinnesotaUSA

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