The Connection between Amino Acids, Urinary Enzymes and Stone Formation
About 30 enzymes have been identified in urine, none of whose activities is correlated with calcium oxalate (CaOx) kidney stone disease1. Recently, however, we reported2 a significant difference in the activities of the urinary transaminase enzymes (GOT and GPT) between stone formers (SF) and normals. The average activity values of GOT and GPT in normal urines were found to be higher than those of SF by a factor of 3. GOT and GPT convert aspartic acid and alanine to glutamic acid. In vitro and in vivo studies3,4 showed that glutamic acid is a potent inhibitor for CaOx precipitation. In this study the role of GOT and GPT activity in CaOx stone formation were studied along with evaluation of the effect of drug treatment on it.
KeywordsGlutamic Acid Kidney Stone Stone Former Calcium Oxalate Kidney Stone Disease
Unable to display preview. Download preview PDF.