The Connection between Amino Acids, Urinary Enzymes and Stone Formation

  • R. Azoury
  • S. Perlberg
  • N. Garti
  • Y. Wax
  • S. Sarig
Conference paper

Abstract

About 30 enzymes have been identified in urine, none of whose activities is correlated with calcium oxalate (CaOx) kidney stone disease1. Recently, however, we reported2 a significant difference in the activities of the urinary transaminase enzymes (GOT and GPT) between stone formers (SF) and normals. The average activity values of GOT and GPT in normal urines were found to be higher than those of SF by a factor of 3. GOT and GPT convert aspartic acid and alanine to glutamic acid. In vitro and in vivo studies3,4 showed that glutamic acid is a potent inhibitor for CaOx precipitation. In this study the role of GOT and GPT activity in CaOx stone formation were studied along with evaluation of the effect of drug treatment on it.

Keywords

Glutamic Acid Kidney Stone Stone Former Calcium Oxalate Kidney Stone Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    H. Mattenheimer, in: “Methods of Enzymatic Analysis”, H. U. Bergmeyer, ed., Verlag Chemie, Weinheim (1974).Google Scholar
  2. 2.
    R. Azoury, N. Garti, S. Perlberg, S. Sarig, Urol. Res., 10:185 (1982).PubMedGoogle Scholar
  3. 3.
    M. G. McGeown, Urology 78:381 (1957).Google Scholar
  4. 4.
    R. Azoury, S. Sarig, N. Garti, S. Perlberg, Urol. Res. 10:169 (1982).PubMedGoogle Scholar
  5. 5.
    S. Sarig, N Garti, R. Azoury, Y. Wax, and S. Perlberg, J. Urol. 128:645 (1982).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • R. Azoury
    • 1
  • S. Perlberg
    • 1
  • N. Garti
    • 1
  • Y. Wax
    • 1
  • S. Sarig
    • 1
  1. 1.The Casali Institute of Applied ChemistryThe Hebrew University of JerusalemJerusalemIsrael

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