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Activity of Adenine Phosphoribosyltransferase (Aprt) in Patients with Renal Failure and Urolithiasis

  • A. Stenzel
  • P. Banholzer
  • W. Löffler
  • S. Reiter
  • W. Gröbner
  • N. Zöllner
  • M. Hegemann
  • R. Pfab
Conference paper

Abstract

The common clinical manifestation of complete APRT-deficiency is 2,8-dihydroxyadenine (2,8-DHA) urolithiasis. Acute and chronic renal failure have also been reported1. On the other hand, homozygotes, either with late onset2or without symptoms3, have been described. Heterozygous patients are usually symptom-free and only occasionally form stones. It has been suggested that APRT-deficiency might not be a rare disease and is often overlooked in patients with renal failure or urolithiasis1. Thus, screening for APRT-deficiency in these patients seemed worthwhile.

Keywords

Uric Acid Chronic Renal Failure Calcium Oxalate Unselected Patient Receive Blood Transfusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • A. Stenzel
    • 1
  • P. Banholzer
    • 1
  • W. Löffler
    • 1
  • S. Reiter
    • 1
  • W. Gröbner
    • 1
  • N. Zöllner
    • 1
  • M. Hegemann
    • 1
  • R. Pfab
    • 1
  1. 1.Medizinische Poliklinik der Universität München and Urologische Klinik und Poliklinik der TechnischenUniversität MünchenGermany

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