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Proximal Tubule Sodium Handling in Calcium Stone Formers

  • G. Colussi
  • M. E. De Ferrari
  • P. Cosci
  • B. Corradi
  • E. Benazzi
  • G. Pontoriero
  • G. Rombola
  • L. Minetti
Conference paper

Abstract

It has been suggested that a high Na intake might be an etiological factor in idiopathic hypercalciuria (IH) and that in hypercalciuric Ca stone formers (CSF), Ca excretion (UCaV) can be normalized by reducing Na intake to less than 100 mEq/day without any change in Ca intake1. Moreover, in IH there might exist a proximal tubular “defect” in which there is reduced fractional reabsorption of Na, fluid, P, and possibly, Ca and Mg2,3. However, since the proximal tubule “defect” for Na is compensated at more distal sites of the tubule it cannot be the sole cause of the increased urinary Na excretion commonly seen in hypercalciuric patients1,3. We conclude that hypercalciuric patients must have an increased Na intake and have studied the relationship between Na intake, proximal tubular Na reabsorption and UCaV in healthy people and in a group of CSF to clarify the issue.

Keywords

Idiopathic Hypercalciuria Free Water Clearance Distal Delivery Fractional Delivery Fractional Reabsorption 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    F. D. Muldowney, R. Freaney, and F. Maloney, Kidney Int. 22:292 (1982).PubMedCrossRefGoogle Scholar
  2. 2.
    A. L. Sutton and V. R. Walker, New Engl. J. Med. 13:709 (1980).CrossRefGoogle Scholar
  3. 3.
    Y. K. Lau, H. Wasserstein, G. R. Westbey, P. Bosanac, M. Gabrie, P. Mitnick, E. Slatopolsky, S. Goldfarb, and Z. S. Agus, Min. Electrol. Metab. 7:237 (1982).Google Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • G. Colussi
    • 1
  • M. E. De Ferrari
    • 1
  • P. Cosci
    • 1
  • B. Corradi
    • 1
  • E. Benazzi
    • 1
  • G. Pontoriero
    • 1
  • G. Rombola
    • 1
  • L. Minetti
    • 1
  1. 1.Renal UnitsCa’ Granada Niguarda Hospital, Milan and Ospedale MaggioreLodiItaly

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