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Hyperuricosuric Calcium Stoneformers: Effect on Fasting and Calcium Hyperabsorption

  • V. R. Walker
  • R. A. L. Sutton
Conference paper

Abstract

We have previously reported that serum urate, urinary urate and the fractional excretion of urate (FEurate) do not differ between male idiopathic Ca stoneformers and normal subjects, following an overnight fast, and a similar non-linear negative correlation exists between FEurate and serum urate levels in these two groups1. This latter observation demonstrates the role of the kidney in altering the distribution of urate between serum and urine. In 24-h non-fasting urine collections, Coe2 has reported a 29% incidence of hyperuricosuria in Ca stoneformers. This value is similar to the 33% incidence we have found in male Ca stoneformers (urine urate > 800 mg/day). Coe and Kavalich3 have suggested that excessive dietary purine may be a major factor contributing to hyperuricosuria in these patients. The present study examines other factors, apart from dietary purine, that may alter urinary urate excretion in idiopathic Ca stoneformers.

Keywords

Fractional Excretion Volume Excretion Urine Collection Nephroli Thiasis Serum Urate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    V. R. Walker and R. A. L. Sutton, Calc. Tiss. Int. 35 (Suppl.):A39 (1983).Google Scholar
  2. 2.
    F. L. Coe, in: “Nephrolithiasis, Pathogenesis and Treatment”, F. L. Coe, ed., Year Book Medical Publishers, Chicago (1978).Google Scholar
  3. 3.
    F. L. Coe and A. G. Kavalich, New Engl. J. Med. 291:1344 (1974).PubMedCrossRefGoogle Scholar
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    V. R. Walker and R. A. L. Sutton, Clin. Sci. 66:193 (1984).PubMedGoogle Scholar
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    T. H. Steele, J. Lab. Clin. Med. 74:288 (1969).PubMedGoogle Scholar
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    E. L. Weinman, G. Eknoyan, and W. N. Suki, J. Clin. Invest. 55:283 (1975).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • V. R. Walker
    • 1
  • R. A. L. Sutton
    • 1
  1. 1.Dept. of MedicineUniversity of British ColumbiaVancouverCanada

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