Relation Between Hypercalciuria and Vitamin D3-Status in Renal Stone Formers
An increased urinary excretion of calcium is common among patients with recurrent urolithiasis. Another common abnormality is a low-normal or subnormal serum phosphate level, the latter being a stimulus for the renal conversion of 25-hydroxyvitamin D3 (25-OH D3) into the most active metabolite, 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3.) Increased serum levels of 1,25-(OH)2 D3 have been demonstrated in renal stone formers 3 and in patients with hypercalciuria4. The major circulating form of vitamin D3 is, however, 25-(OH) D3 and this metabolite is believed to reflect best the endogenous synthesis and stores of vitamin D3 5. Previous attempts to demonstrate increased concentrations of 25-(OH) D3 in serum from patients who form renal stones have failed2,3. Whether or not the pool of 25-OH D3 is increased in hypercalciuria is not known. In order to study this possibility, we have determined 25-OH D3 in stone forming patient with or without hypercalciuria.
KeywordsRenal Stone Serum Phosphate Calcium Excretion Lower Serum Phosphate Huddinge Hospital
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