The Effect of Ingestion of Megadoses of Ascorbic Acid on Urinary Oxalate Excretion in Normal Subjects and Stone Formers
In Western countries megadoses of ascorbic acid, ranging from 3 to 30 g, are being advocated as prophylactic and therapeutic measures against several diseases, notably the common cold and certain malignant conditions1−6. In India, it is common practice to use ascorbic acid in doses between 200 and 1000 mg/day during the post-operative period to achieve faster wound healing and to counter infection but there is an increased trend towards the use of megadoses of ascorbic acid.
KeywordsAscorbic Acid Oxalic Acid Calcium Oxalate Urinary Oxalate Urinary Oxalate Excretion
Unable to display preview. Download preview PDF.
- 2.A. Hodgkinson, “Oxalic Acid in Biology and Medicine”, Academic Press, London (1977).Google Scholar
- 3.E. Cameron, L. Pauling, and B. Leibowitz, Rev. Canc. Res. 39:663 (1979).Google Scholar
- 7.A. K. Pendse, A. K. Srivastava, J. L. Kumawat, H. S. Sharma, R. Ghosh, A. Goyal, and P. P. Singh, Int. Cell. Surg. Bull. 188: (1982).Google Scholar
- 8.P. P. Singh, A. K. Pendse, R. Ghosh, and A. Goyal, Asian Med. J. (in press).Google Scholar
- 10.L. H. Smith, New Engl. J. Med. 298:856 (1978).Google Scholar
- 11.S. Natelson, “Techniques of Clinical Chemistry”, Charles C. Thomas, Springfield (1971).Google Scholar
- 13.H. Varley, A. H. Gowenlock and M. Bell, “Practical Clinical Biochemistry”, Vol. I, Heinemann, London (1976).Google Scholar