Red Blood Cell Transmembrane Oxalate Flux in Idiopathic Calcium Oxalate Nephrolithiasis
The occurrence of mild hyperoxaluria “idiopathic” calciumoxalate (CaOx) stone disease has been stressed recently1,2 It is thought to be due to a higher than normal intestinal absorption of oxalate3,4, although abnormal renal handling of the ion cannot be ruled out. The underlying mechanism of both these abnormalities might involve a defect in the cellular transport of oxalate. To test this hypothesis, we have compared the rates of oxalate transport in red blood cells (RBC) in “idiopathic” CaOx stone forming patients and normal subjects. The results of this study are reported here.