The Effect of Indomethacin and Flurbiprofen on Calcium Excretion and Glomerular Filtration Rate in the Anaesthetized Rat
Calcium stone disease is commonly associated with hyper-calciuria which, if left untreated, can lead to a high incidence of recurrent stone formation1,2. It has been shown recently that the prostaglandin synthetase inhibitors, indomethacin and flurbiprofin, restore Ca excretion to normal in patients with idiopathic hyper-calciuria and it has been suggested that they may be useful in treating this disorder3,4. In conscious experimental animals indomethacin reduces Ca, Na and water excretion without associated changes in renal haemodynamics5,6 implicating a role for prostaglandins in the regulation of Ca excretion by a direct action on the tubular transport processes. Prior to studying possible prostaglandin-Ca interaction in the nephron by micropuncture, we have investigated the effects of indomethacin and flurbiprofen on renal haemodynamics and Ca excretion in the anaesthetized rats.
KeywordsGlomerular Filtration Rate Renal Plasma Flow Recurrent Stone Effective Renal Plasma Flow Renal Haemodynamics
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