Relation of Severity Of Renal Impairment to Tissue Calcium Concentration in the Human Kidney
Ibels et al1 recently reported that calcium in kidneys from patients with end-stage renal disease is 8-fold greater than in normal kidneys. We have extended these observations by examining the calcium content of renal tissue obtained at biopsy and representing a wide range of severity of renal impairment. This preliminary report focuses upon two questions: (i) Can a correlation be demonstrated between the concentration of calcium within the kidney and the degree of functional impairment? (ii) Does phosphate play a significant role as a determinant of renal calcification in human renal disease?
KeywordsRenal Impairment Impaired Renal Function Renal Tissue Serum Phosphate Phosphate Restriction
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