Relation of Severity Of Renal Impairment to Tissue Calcium Concentration in the Human Kidney

  • L. Gimenez
  • K. Solez
  • W. G. Walker
Conference paper


Ibels et al1 recently reported that calcium in kidneys from patients with end-stage renal disease is 8-fold greater than in normal kidneys. We have extended these observations by examining the calcium content of renal tissue obtained at biopsy and representing a wide range of severity of renal impairment. This preliminary report focuses upon two questions: (i) Can a correlation be demonstrated between the concentration of calcium within the kidney and the degree of functional impairment? (ii) Does phosphate play a significant role as a determinant of renal calcification in human renal disease?


Renal Impairment Impaired Renal Function Renal Tissue Serum Phosphate Phosphate Restriction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    L. Ibels, A. Alfrey, W. Huffer, P. Craswell, and R. Weil, Am. J. Med. 71:33 (1981).PubMedCrossRefGoogle Scholar
  2. 2.
    W. Tew, C. Malis, and W. G. Walker, Analyt. Biochem. 112:346 (1981).PubMedCrossRefGoogle Scholar
  3. 3.
    L. Ibels, A. Alfrey, L. Haut, and W. Huffer, New Engl. J. Med. 298:122 (1978).PubMedCrossRefGoogle Scholar
  4. 4.
    L. Haut, A. Alfrey, S. Guggenheim, B. Buddington, and N. Schrier, Kidney Int. 17:722 (1980).PubMedCrossRefGoogle Scholar
  5. 5.
    L. Gimenez, W. G. Walker, W. Tew, and J. Hermann, Kidney Int. 22:36 (1982).PubMedCrossRefGoogle Scholar
  6. 6.
    V. Collier, W. Mitch, and M. Walser, Clin. Res. 26:564A (1978).Google Scholar
  7. 7.
    M. Walser, W. Mitch, and V. Collier, Clin. Nephrol. 11:66 (1979).PubMedGoogle Scholar
  8. 8.
    M. Walser, W. Mitch, and V. Collier, jr: “Contributions to Nephrology”, G. Berlyne, ed., S. Karger, Basel (1980).Google Scholar
  9. 9.
    G. Maschio, L. Oldrizzi, N. Tessitore, A. D’Angelo, E. Valvo, A. Lupo, C. Loschiavo, A. Fabris, L. Gammaro, C. Rugiu, and G. Panzetta, Kidney Int. 22:371 (1982).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • L. Gimenez
    • 1
  • K. Solez
    • 1
  • W. G. Walker
    • 1
  1. 1.Depts. of Medicine and PathologyJohn Hopkins University School of Medicine and the John Hopkins HospitalBaltimoreUSA

Personalised recommendations