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Effects of Metabolic Acidosis and Alkalosis on the Renal Brush Border Membrane Transport of Citrate

  • A. D. Jenkins
  • T. P. Dousa
  • L. H. Smith
Conference paper

Abstract

The systemic acidosis in patients with distal renal tubular acidosis (RTA) may be responsible for the hypocitraturia1. The ability of renal mitochondria to metabolize citrate via the tricarboxylic acid cycle is thought to control the renal clearance of citrate. Metabolic acidosis increases the entry of citrate into the matrix space of mitochondria, cytoplasmic citrate levels fall, reabsorption of citrate from tubular fluid is enhanced, and less citrate appears in the final urine. Metabolic alkalosis has an opposite effect1.

Keywords

Metabolic Acidosis Brush Border Membrane Renal Tubular Acidosis Metabolic Alkalosis Brush Border Membrane Vesicle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • A. D. Jenkins
    • 1
  • T. P. Dousa
    • 1
  • L. H. Smith
    • 1
  1. 1.Nephrology Research UnitMayo ClinicRochesterUSA

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