Effects of Metabolic Acidosis and Alkalosis on the Renal Brush Border Membrane Transport of Citrate
The systemic acidosis in patients with distal renal tubular acidosis (RTA) may be responsible for the hypocitraturia1. The ability of renal mitochondria to metabolize citrate via the tricarboxylic acid cycle is thought to control the renal clearance of citrate. Metabolic acidosis increases the entry of citrate into the matrix space of mitochondria, cytoplasmic citrate levels fall, reabsorption of citrate from tubular fluid is enhanced, and less citrate appears in the final urine. Metabolic alkalosis has an opposite effect1.
KeywordsMetabolic Acidosis Brush Border Membrane Renal Tubular Acidosis Metabolic Alkalosis Brush Border Membrane Vesicle
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- 1.D. P. Simpson, Am. J. Physiol. 244:F223 (1982).Google Scholar