Intestinal Absorption of Oxalate in Gonadectomized Rats
Hyperabsorption of oxalate from the gut has been shown to be an important contributory factor in the production of calcium oxalate urolithiasis1, a disease which is more prevalent in men than women2. Sex hormones regulate the enzymes of oxalate biosynthesis in the glycolate-glyoxylate-oxalate pathways3,4. To elucidate the role of sex hormones in the intestinal uptake of oxalate, male and female rats were gonadectomized and treated with estradiol and testosterone respectively.
KeywordsSialic Acid Calcium Oxalate Brush Border Membrane Oxalate Excretion Castrate Male
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