Mechanism of Sodium Glycolate Absorption in Rat Intestine
Glycolic acid is a precursor of oxalate in animals and man and the importance of it in the diet as a cause of increased urinary oxalate has recently been emphasised1. Under normal physiological conditions only 5% of dietary glycolate is converted to urinary oxalate, amounting to about 20 mg oxalate per day. This conversion rate, however, increases 18-fold in conditions such as pyridoxine deficiency2,3. Because of the wide-spread evidence of subclinical pyridoxine deficiency in the population4,5, dietary glycolate may be enormously important as an oxalate precursor. However, no data are available on the mechanism of intestinal absorption of glycolate and its alterations in vitamin B6 deficiency. The present study was undertaken to elucidate the mechanism of the intestinal transport of glycolate in rats and to study how it is effected by pyridoxine deficiency.
KeywordsGlycolic Acid Sodium Lactate Urinary Oxalate Iodoacetic Acid Oxalate Sodium
Unable to display preview. Download preview PDF.