Kinetic Study of the Intestinal Calcium-Binding Protein in Absorptive Hypercalciuria

  • B. Pinto
  • M. A. Vilanova
  • F. J. Ruiz-Marcellan
  • J. Bernshtam
Conference paper


Hypercalciuria is found in 48.8% of recurrent stone formers1. Hyperabsorption, bone resorption2 or a renal leak of calcium are the possible causes of hypercalciuria. Intestinal hyperabsorption of calcium may be due to a renal leak of phosphorus followed by an increased synthesis of 1,25-dihydroxycholecalciferol (1,25-(OH)2D3)4. Alternatively, it has been suggested that the hyperabsorption is due to a higher calcium transport without increased synthesis of the vitamin D3 metabolites5, perhaps mediated by a specific protein existing in the brush border cells6. The purpose of this paper was to investigate the roles of the calcium-binding protein (CaBP) and 1,25-(OH)2D3 in absorptive hypercalciuric stone formers and normal control subjects.


Normal Control Subject Scatchard Plot Recurrent Stone Oxalate Excretion Recurrent Stone Formers1 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • B. Pinto
    • 1
  • M. A. Vilanova
    • 1
  • F. J. Ruiz-Marcellan
    • 1
  • J. Bernshtam
    • 1
  1. 1.Servicio de Analisis ClinicosHospital Joan XXIII Tarragona and Servicio de Urologia Hospital Valle HebronBarcelonaSpain

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