Kinetic Study of the Intestinal Calcium-Binding Protein in Absorptive Hypercalciuria
Hypercalciuria is found in 48.8% of recurrent stone formers1. Hyperabsorption, bone resorption2 or a renal leak of calcium are the possible causes of hypercalciuria. Intestinal hyperabsorption of calcium may be due to a renal leak of phosphorus followed by an increased synthesis of 1,25-dihydroxycholecalciferol (1,25-(OH)2D3)4. Alternatively, it has been suggested that the hyperabsorption is due to a higher calcium transport without increased synthesis of the vitamin D3 metabolites5, perhaps mediated by a specific protein existing in the brush border cells6. The purpose of this paper was to investigate the roles of the calcium-binding protein (CaBP) and 1,25-(OH)2D3 in absorptive hypercalciuric stone formers and normal control subjects.
KeywordsNormal Control Subject Scatchard Plot Recurrent Stone Oxalate Excretion Recurrent Stone Formers1
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