Nephrolithiasis Associated with Intestinal Disease

  • J. W. Dobbins


It has been noted since the 1960∲s that there is an increased incidence of nephrolithiasis in patients with idiopathic inflammatory bowel disease and in individuals who have undergone jejuno-ileal bypass for obesity1−14. In patients with inflammatory bowel disease, prior surgical treatment increases the risk of nephrolithiasis7,9,10. The incidence of nephrolithiasis in patients with Crohn’s disease who have undergone an ileal resection is approximately 10%. The large majority of these stones, when analyzed, are composed of calcium oxalate. The incidence of nephrolithiasis in patients with ulcerative colitis who have undergone an ileostomy is also approximately 10%. Uric acid stones, however, make up a significant proportion of the calculi in these patients1−3. The incidence of nephrolithiasis in patients who have undergone jejuno-ileal bypass for obesity is 20% or more.


Bile Acid Calcium Oxalate Medium Chain Fatty Acid Uric Acid Stone Urinary Abnormality 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • J. W. Dobbins
    • 1
  1. 1.Dept. of Internal MedicineYale UniversityNew HavenUSA

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