Urine and Serum Biochemistry Relative to the Risk of Lithogenesis in Rats on an Atherogenic Diet
Several animal models have been established to study the effect of dietary changes on the pathogenesis of urolithiasis. For example, an atherogenic diet (rich in cholesterol) fed to rats causes nephrocalcinosis and urolithiasis1,2. These changes occur within 3 to 4 weeks. The pathophysiological mechanisms, however, are not clear. Changes occur in the pancreatic islets (an increase in the total number of A-cells) which result in an increased production of glucagon and an effect on calcium metabolism and this may be the cause of the renal calcification1,2. The purpose of this study was to examine these interrelationships.
KeywordsPancreatic Islet Control Diet Dietary Change Calcium Metabolism Renal Tubular Acidosis
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