Urinary Stone Matrix and Urinary Macromolecules

  • S. D. Roberts
  • M. I. Resnick


The role of matrix and urinary macromolecules and urinary macromolecules in the formation of urinary stones is poorly understood. Matrix has been implicated by some as a necessary substrate for crystal formation1 and by others as a mere co-precipitant with inorganic crystals2,3. Several urinary macromolecules have been identified but their importance in matrix and stone formation remains obscure. The purpose of this report is to review current knowledge on these complex components of urinary calculi.


Sialic Acid Stone Formation Calcium Oxalate Urinary Stone Urinary Calculus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    W. H. Boyce, Am. J. Med. 45:673 (1968).PubMedCrossRefGoogle Scholar
  2. 2.
    C. W. Vermeulen and E. S. Lyon, Am. J. Med. 45:684 (1968).PubMedCrossRefGoogle Scholar
  3. 3.
    B. T. Murphy and L. N. Pyrah, Br. J. Urol. 34:129 (1962).PubMedCrossRefGoogle Scholar
  4. 4.
    A. J. Butt, “Etiologic Factors in Renal Lithiasis”, C. T. Thomas, Springfield (1956).Google Scholar
  5. 5.
    W. H. Boyce and F. K. Garvey, J. Urol. 76:213 (1956).PubMedGoogle Scholar
  6. 6.
    W. H. Boyce, in:“Urolithiasis:Physical Aspects”, B. Finlayson, L. L. Hench, and L. H. Smith, eds., National Academy of Sciences, Washington (1972).Google Scholar
  7. 7.
    R. S. Malek and W. H. Boyce, J. Urol. 117:336 (1977).PubMedGoogle Scholar
  8. 8.
    W. H. Boyce and N. M. Sulkin, J. Clin. Invest. 35:1067 (1956).PubMedCrossRefGoogle Scholar
  9. 9.
    J. S. King and W. H. Boyce, Arch. Biochem. Biophys. 82:455 (1959).PubMedCrossRefGoogle Scholar
  10. 10.
    J. S. King and W. H. Boyce, Soc. Exp. Biol. Med. 95:183 (1957).Google Scholar
  11. 11.
    M. A. Warpehoski, R. J. Buscemi, D. C. Osborn, B. Finlayson, and E. P. Goldberg, Calcif. Tiss. Int. 33:211 (1981).CrossRefGoogle Scholar
  12. 12.
    A. R. Spector, A. Gray and E. L. Prien, Invest. Urol. 13:387 (1976).PubMedGoogle Scholar
  13. 13.
    W. G. Robertson, D. S. Scurr, and C. M. Bridge, J. Cryst. Growth 53:182 (1981).CrossRefGoogle Scholar
  14. 14.
    Y. Kimura, N. Kiaki, and K. Ise, Urol.Int. 31:355 (1976).PubMedCrossRefGoogle Scholar
  15. 15.
    W. H. Boyce, in: “Proteins in Normal and Pathologic Urine”, Y. Manue, J. P. Revillard, and H. Beutel, eds., Karger, Basel (1970).Google Scholar
  16. 16.
    W. H. Boyce and J. S. King, J. Urol. 81:351 (1959).PubMedGoogle Scholar
  17. 17.
    R. C. Boyer, J. G. Brockis, and R. K. McCulloch, Clin. Chim. Acta 95:23 (1979).CrossRefGoogle Scholar
  18. 18.
    J. J. Leal and B. Finlayson, Invest. Urol. 14:278 (1977).PubMedGoogle Scholar
  19. 19.
    T. Kitamura, J. E. Zerwekh, and C. Y. C. Pak, Kidney Int. 21:379 (1982).PubMedCrossRefGoogle Scholar
  20. 20.
    G. W. Drach, S. Sarig, and A. D. Randolph, Urol. Res. 10:165 (1982).PubMedCrossRefGoogle Scholar
  21. 21.
    R. L. Ryall, R. M. Harnett, and V. R. Marshall, Clin. Chim. Acta 112:349 (1981).PubMedCrossRefGoogle Scholar
  22. 22.
    W. O. Foye, H. S. Hong, C. M. Kim, and E. L. Prien, Invest. Urol. 14:33 (1976).PubMedGoogle Scholar
  23. 23.
    R. K. McCulloch, R. C. Bowyer, and J. G. Brockis, in: “Urinary Calculus”, J. G. Brockis and B. Finlayson, eds., P. S. G. Publishing Co. Littleton (1981).Google Scholar
  24. 24.
    W. H. Boyce, J. S. King, and M. L. Fielden, J. Clin. Invest. 41:5 (1962).CrossRefGoogle Scholar
  25. 25.
    J. B. Lian, E. L. Prien, J. M. Glimcher, and P. M. Gallop, J. Clin. Invest. 59:1151 (1977).PubMedCrossRefGoogle Scholar
  26. 26.
    J. B. Lian, J. T. Levy, and P. A. Friedman, in: “Calcium Binding Proteins:Structure and Function”, F. L. Siegel, E. Carafoli, R. H. Kretsinger, D. H. Maclennan, and R. H. Wasserman, eds., Elsevier, Amsterdam (1980).Google Scholar
  27. 27.
    J. Joost, S. Silbernagl, and E. Jarosch,in: “Urolithiasis: Clinical and Basic Research”, L. H. Smith, W. G. Robertson, and B. Finlayson, eds., Plenum, New York (1980).Google Scholar
  28. 28.
    M. I. Resnick, O. W. Gammon, M. B. Sorrell, and W. H. Boyce, Surgery 88:239 (1980).PubMedGoogle Scholar
  29. 29.
    J. S. King and W. H. Boyce, Ann. N. Y. Acad. Sci. 104:579 (1963).CrossRefGoogle Scholar
  30. 30.
    R. S. Malek and W. H. Boyce, J. Urol. 109:579 (1963).Google Scholar
  31. 31.
    H. J. Keutel and J. S. King, Invest. Urol. 2:115 (1964).PubMedGoogle Scholar
  32. 32.
    W. H. Boyce and J. S. King, Ann. N. Y. Acad. Sci. 104:563 (1963).PubMedCrossRefGoogle Scholar
  33. 33.
    S. Moore and G. Gowland, J. Urol 47:489 (1975).CrossRefGoogle Scholar
  34. 34.
    I. Tamm and F. L. Horsfall, Proc. Soc. Exp. Biol.Med. 17:108 (1950).Google Scholar
  35. 35.
    I. Tamm and F. L. Horsfall, J. Exp. Med. 95:71 (1951).CrossRefGoogle Scholar
  36. 36.
    G. E. Perlmann, I. Tamm, and F. L. Horsfall, J. Exp. Med. 95:99 (1951).CrossRefGoogle Scholar
  37. 37.
    J. K. McKenzie and E. G. McQueen, J. Clin. Path. 22:334 (1969).PubMedCrossRefGoogle Scholar
  38. 38.
    M. Maxfield, Biochim. Biophys. Acta 49:548 (1961).PubMedCrossRefGoogle Scholar
  39. 39.
    A. J. Pesce and M. R. First, “Proteinuria:An Integrated Review”, Marcel Dekker, 1979.Google Scholar
  40. 40.
    P. C. Hallson and G. A. Rose, Lancet 1:1000 (1979).PubMedCrossRefGoogle Scholar
  41. 41.
    M. Maxfield, Ann. Rev. Med. 14:99 (1963).PubMedCrossRefGoogle Scholar
  42. 42.
    W. H. Boyce, in: “Biology of Hard Tissue”, Vol. 1. A. M. Budy, ed., New York Acad Science (1967).Google Scholar
  43. 43.
    T. Mutton, M. I. Resnick, and W. H. Boyce, Invest. Urol. 15:419 (1978).PubMedGoogle Scholar
  44. 44.
    R. A. Melick, K. J. Quelch, and M. Rhodes, Clin. Sci. 59:401 (1980).PubMedGoogle Scholar
  45. 45.
    S. R. Khan, B. Finlayson, and R. L. Hackett, Scan. Electron Microsc. 1:379 (1983).Google Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • S. D. Roberts
    • 1
  • M. I. Resnick
    • 1
  1. 1.Division of UrologyCase Western Reserve University School of MedicineClevelandUSA

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