Round Table Discussion on the Comparison of Models for the Study of Inhibitory Activity in Urine
The processes which lead to the formation of the solid phase of urinary stones include crystal nucleation, growth and aggregation. Inhibitors are defined as substances which slow down any of these processes by a mechanism which does not depend on decreasing the concentration of crystal-forming ions, but on an action at the developing surface of the embryo or crystal itself. The panelists decided to cover only techniques involving the crystallisation of calcium phosphate and calcium oxalate. The methods presented were roughly divided into those techniques where (1) crystallisation is induced by increasing the concentration(s) of stone-forming ion(s), (2) seed crystals are added to a metastable system and (3) crystallisation is followed under conditions of constant fluid composition, although some overlap between the various systems occurs.
KeywordsCalcium Phosphate Calcium Oxalate Urinary Stone Seed Crystal Potassium Citrate
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