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N-Sulfo-2-Amino Tricarballylate, A New Analog of Phosphocitrate: Metabolism and Inhibitory Effects on Renal Calcification

  • M. R. Brown
  • J. D. Sallis

Abstract

Although the mechanism of action of urinary inhibitors has not been fully elucidated, most authors agree that measures which increase endogenous or exogenous inhibitors prevent kidney stone disease. As a therapeutic agent, an inhibitor should be well absorbed when given orally, potently effective with minimal side-effects, target specific and rapidly cleared. Few compounds meet these criteria. Phosphociträte (PC), a naturally occurring, inhibitor of calcification in vitro appears to be promising but is susceptible to enzyme hydrolysis. This led us to develop a more stable PC analog, N-sulfo-2-amino tricarballylate (SAT) (Fig. 1).

Keywords

Calcium Oxalate Massive Deposition Calcium Gluconate Sodium Oxalate CaOx Crystal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    M. R. Brown and J. D. Sallis, Analyt. Biochem. 132:115 (1983).PubMedCrossRefGoogle Scholar
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    G. Williams and J. D. Sallis, Analyt. Biochem. 102:169 (1980).CrossRefGoogle Scholar
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    W. P. Tew, C. D. Malis, J. E. Howard, and A. L. Lehninger, Proc. Nat. Acad. Sci. 78:5528 (1981).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • M. R. Brown
    • 1
  • J. D. Sallis
    • 1
  1. 1.Biochemistry DeptUniversity of TasmaniaAustralia

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