N-Sulfo-2-Amino Tricarballylate, A New Analog of Phosphocitrate: Metabolism and Inhibitory Effects on Renal Calcification

  • M. R. Brown
  • J. D. Sallis


Although the mechanism of action of urinary inhibitors has not been fully elucidated, most authors agree that measures which increase endogenous or exogenous inhibitors prevent kidney stone disease. As a therapeutic agent, an inhibitor should be well absorbed when given orally, potently effective with minimal side-effects, target specific and rapidly cleared. Few compounds meet these criteria. Phosphociträte (PC), a naturally occurring, inhibitor of calcification in vitro appears to be promising but is susceptible to enzyme hydrolysis. This led us to develop a more stable PC analog, N-sulfo-2-amino tricarballylate (SAT) (Fig. 1).


Calcium Oxalate Massive Deposition Calcium Gluconate Sodium Oxalate CaOx Crystal 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • M. R. Brown
    • 1
  • J. D. Sallis
    • 1
  1. 1.Biochemistry DeptUniversity of TasmaniaAustralia

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