Advertisement

The Contribution of the Bladder to Calcium Oxalate Crystal Growth Inhibition in Voided Urine

  • X. Martin
  • T. J. Opgenorth
  • P. G. Werness
  • R. T. Rundquist
  • J. C. Romero
  • L. H. Smith

Abstract

Large molecular weight inhibitors of calcium oxalate crystal growth and aggregation have been partially characterized in human urine1. These inhibitors include glycosaminoglycans, RNA-like substances, and acidic glycoproteins, and are thought to represent the most important part of the inhibition of calcium oxalate crystal formation in urine. The uroepithelium of the bladder is covered with the glycocalyx, a mucous coat containing glycosaminoglycans2. The existence of glycosaminoglycans at the level of the bladder opens the possibility that part of the mucous substance covering the bladder may be discharged in urine, thus modifying its composition with respect to glycosaminoglycans, and its ability to inhibit calcium oxalate crystal growth.

Keywords

Bladder Urine Urine Collection Calcium Oxalate Calcium Oxalate Crystal Acidic Glycoprotein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    W. G. Robertson, D. S. Scurr, and C. M. Bridge, J. Cryst. Growth 53:182 (1981).CrossRefGoogle Scholar
  2. 2.
    C. L. Parson, C. Stauffer, and J. D. Schmidt, Science 208:605 (1980).CrossRefGoogle Scholar
  3. 3.
    J. L. Meyer and L. H. Smith, Invest. Urol. 13:31 (1975)PubMedGoogle Scholar
  4. 4.
    P. Whiteman, Biochem. J. 131:351 (1973).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • X. Martin
    • 1
  • T. J. Opgenorth
    • 1
  • P. G. Werness
    • 1
  • R. T. Rundquist
    • 1
  • J. C. Romero
    • 1
  • L. H. Smith
    • 2
  1. 1.Mayo Clinic and Mayo FoundationNephrology Research UnitRochesterUSA
  2. 2.Service d’Urologie et de Chirurgie de la TransplantationHôpital E. HerriotLyonFrance

Personalised recommendations