The Contribution of the Bladder to Calcium Oxalate Crystal Growth Inhibition in Voided Urine
Large molecular weight inhibitors of calcium oxalate crystal growth and aggregation have been partially characterized in human urine1. These inhibitors include glycosaminoglycans, RNA-like substances, and acidic glycoproteins, and are thought to represent the most important part of the inhibition of calcium oxalate crystal formation in urine. The uroepithelium of the bladder is covered with the glycocalyx, a mucous coat containing glycosaminoglycans2. The existence of glycosaminoglycans at the level of the bladder opens the possibility that part of the mucous substance covering the bladder may be discharged in urine, thus modifying its composition with respect to glycosaminoglycans, and its ability to inhibit calcium oxalate crystal growth.
KeywordsBladder Urine Urine Collection Calcium Oxalate Calcium Oxalate Crystal Acidic Glycoprotein
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