Further Studies on the Possible Lithogenetic Role of Uric Acid in Calcium Oxalate Stone Disease
The possible role of uric acid in aggravating recurrent “idiopathic” calcium oxalate (CaOx) nephrolithiasis is still a matter of discussion. Substantially, two hypotheses have been advanced; the first proposes direct induction of CaOx precipitation by uric acid crystals or colloidal uric acid1,2, while the second suggests that uric acid interferes with the glycosaminoglycan (GAGS) inhibitors of CaOx stone formation3–5. Since the urine of CaOx stone formers is generally free from uric acid crystals6,7, theories assigning a primary role to uric acid crystals seem untenable; that there is binding between uric acid and GAGS which reduces GAGS inhibitory activity on CaOx crystal formation seems more feasible, as does the direct action of molecular or colloidal uric acid on CaOx precipitation. The possible existence of a direct bond between uric acid and GAGS is investigated in this study; in addition the likelihood that uric acid directly promotes CaOx precipitation has been evaluated.
KeywordsUric Acid Calcium Oxalate Calcium Oxalate Stone Uric Acid Excretion CaOx Stone
Unable to display preview. Download preview PDF.
- 3.W. G. Robertson, in: “Urolithiasis Research”, H. Fleisch, W. G. Robertson, L. H. Smith and W. Vahlensieck, eds., Plenum, New York (1976).Google Scholar
- 7.J. G. Brockis and R. C. Bowyer, in: “Urolithiasis, Clinical and Basic Research”, L. H. Smith, W. G. Robertson and B. Finlayson, eds., Plenum, New York (1981).Google Scholar