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Further Studies on the Possible Lithogenetic Role of Uric Acid in Calcium Oxalate Stone Disease

  • B. Baggio
  • G. Bambaro
  • E. Cicerello
  • F. Marchini
  • A. Borsatti
Conference paper

Abstract

The possible role of uric acid in aggravating recurrent “idiopathic” calcium oxalate (CaOx) nephrolithiasis is still a matter of discussion. Substantially, two hypotheses have been advanced; the first proposes direct induction of CaOx precipitation by uric acid crystals or colloidal uric acid1,2, while the second suggests that uric acid interferes with the glycosaminoglycan (GAGS) inhibitors of CaOx stone formation3–5. Since the urine of CaOx stone formers is generally free from uric acid crystals6,7, theories assigning a primary role to uric acid crystals seem untenable; that there is binding between uric acid and GAGS which reduces GAGS inhibitory activity on CaOx crystal formation seems more feasible, as does the direct action of molecular or colloidal uric acid on CaOx precipitation. The possible existence of a direct bond between uric acid and GAGS is investigated in this study; in addition the likelihood that uric acid directly promotes CaOx precipitation has been evaluated.

Keywords

Uric Acid Calcium Oxalate Calcium Oxalate Stone Uric Acid Excretion CaOx Stone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    F. L. Coe, R. L. Lawton, R. B. Goldstein, and V. Tembe, Proc. Soc. Exp. Biol. Med. 149:926 (1975).PubMedGoogle Scholar
  2. 2.
    C. Y. C. Pak and L. H. Arnold. Proc. Soc. Exp. Biol. Med. 149:930 (1975).PubMedGoogle Scholar
  3. 3.
    W. G. Robertson, in: “Urolithiasis Research”, H. Fleisch, W. G. Robertson, L. H. Smith and W. Vahlensieck, eds., Plenum, New York (1976).Google Scholar
  4. 4.
    B. Finlayson and L. Du Bois, Clin. Chem. Acta 84:203 (1978).CrossRefGoogle Scholar
  5. 5.
    C. Y. C. Pak, K. Holt, and J. E. Zerwekh, Invest. Urol. 17:138 (1979).PubMedGoogle Scholar
  6. 6.
    C. Y. C. Pak, D. E. Barilla, K. Holt, L. Brinkley, R. Tolentino, and J. E. Zerwekh, Am. J. Med. 65:593 (1978).PubMedCrossRefGoogle Scholar
  7. 7.
    J. G. Brockis and R. C. Bowyer, in: “Urolithiasis, Clinical and Basic Research”, L. H. Smith, W. G. Robertson and B. Finlayson, eds., Plenum, New York (1981).Google Scholar
  8. 8.
    A. Ligabue, M. Fini, and W. G. Robertson, Clin. Chim. Acta 98:36 (1979).CrossRefGoogle Scholar
  9. 9.
    B. Baggio, G. Gambaro, E. Ossi, S. Favaro, and A. Borsatti, J. Urol. 129:1161 (1983).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • B. Baggio
    • 1
  • G. Bambaro
    • 1
  • E. Cicerello
    • 1
  • F. Marchini
    • 1
  • A. Borsatti
    • 1
  1. 1.Institute of Internal MedicinePostgraduate School of Nephrology, University Hospital, University of PadovaPadovaItaly

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