Hyperuricosuria and Calcium Oxalate Stone Formation
Uric acid is implicated in calcium oxalate (CaOx) kidney stone formation. Crystallographic considerations suggest that uric acid might trigger off calcium oxalate crystallisation by epitaxy1. In vitro experiments on uric acid, however, show negative results, although CaOx growth does occur on sodium urate crystals2. Sodium urate crystals have not been detected in fresh urine and are uncommon in stones and so Robertson suggested that a colloidal gel of urate may be formed that removes natural inhibitors of calcium oxalate aggregation3.
KeywordsUric Acid Calcium Oxalate Uric Acid Concentration Calcium Oxalate Stone Uric Acid Excretion
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- 1.N. S. Mandel and G. S. Mandel, in: “Urolithiasis:Clinical and Basic Research”, L. H, Smith, W. G. Robertson, and B. Finlayson, eds., Plenum, New York (1981).Google Scholar
- 3.W. G. Robertson, F. Knowles, and M. Peacock, in: “Urolithiasis Research”, H. Fleisch, W. G. Robertson, L. H. Smith, and W. Vahlensieck, eds., Plenum, London (1976).Google Scholar