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Hyperuricosuria and Calcium Oxalate Stone Formation

  • B. Goldwasser
  • S. Sarig
  • R. Azoury
  • Y. Wax
  • M. Many

Abstract

Uric acid is implicated in calcium oxalate (CaOx) kidney stone formation. Crystallographic considerations suggest that uric acid might trigger off calcium oxalate crystallisation by epitaxy1. In vitro experiments on uric acid, however, show negative results, although CaOx growth does occur on sodium urate crystals2. Sodium urate crystals have not been detected in fresh urine and are uncommon in stones and so Robertson suggested that a colloidal gel of urate may be formed that removes natural inhibitors of calcium oxalate aggregation3.

Keywords

Uric Acid Calcium Oxalate Uric Acid Concentration Calcium Oxalate Stone Uric Acid Excretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    N. S. Mandel and G. S. Mandel, in: “Urolithiasis:Clinical and Basic Research”, L. H, Smith, W. G. Robertson, and B. Finlayson, eds., Plenum, New York (1981).Google Scholar
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    F. L. Coe, R. L. Lawton, R. B. Goldstein, and V. Tembe, Proc. Soc. Exp. Biol. Med. 149:926 (1975).PubMedGoogle Scholar
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    W. G. Robertson, F. Knowles, and M. Peacock, in: “Urolithiasis Research”, H. Fleisch, W. G. Robertson, L. H. Smith, and W. Vahlensieck, eds., Plenum, London (1976).Google Scholar
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    S. Sarig, N. Garti, R. Azoury, Y. Wax, and S. Perlberg, J. Urol. 128:645 (1982).PubMedGoogle Scholar
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    C. Y. C. Pak, Y. Hayashi, and L. H. Arnold, Proc. Soc. Exp. Biol. Med. 153:83 (1976).PubMedGoogle Scholar
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    S. Sarig, N. Garti, R. Azoury, S. Perlberg, and Y. Wax, J. Urol. 129:1258 (1983).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • B. Goldwasser
    • 1
  • S. Sarig
    • 1
  • R. Azoury
    • 1
  • Y. Wax
    • 1
  • M. Many
    • 1
  1. 1.Dept. of UrologyChaim Sheba Medical Center, Sackler School of Medicine, Tel-Aviv UniversityIsrael

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