The Effect of Uric Acid on The Inhibitory Activity of Glycosaminoglycans and Urine

  • R. L. Ryall
  • R. M. Harnett
  • V. R. Marshall


One theory advanced to explain the apparent influence of urate on calcium oxalate (CaOx) stone formation proposes that the binding of colloidal urate to urinary glycosaminoglycans (GAGS) reduces their inhibitory potency and thereby indirectly increases the risk of CaOx stone formation in vivo1. In this study normal human urine, chondroitin sulphate and heparin were preincubated with uric acid to determine whether or not this altered their inhibitory effect on CaOx crystal growth and aggregation.


Uric Acid Chondroitin Sulphate Calcium Oxalate Inhibitory Potency CaOx Crystal 
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  1. 1.
    W. G. Robertson, F. Knowles, and M. Peacock, in: “Urolithiasis Research”, H. Fleisch, W. G. Robertson, L. H. Smith, and W. Vahlensieck, eds., Plenum, New York (1976).Google Scholar
  2. 2.
    R. L. Ryall, R. M. Harnett, and V. R. Marshall, Clin. Chim. Acta, 112:349 (1981).PubMedCrossRefGoogle Scholar
  3. 3.
    R. G. Ryall, R. L. Ryall, and V. R. Marshall, in: “Urinary Stone”, R. L. Ryall, J. G. Brockis, V. R. Marshall, and B. Finlayson, eds., Churchill Livingstone, Melbourne (1984).Google Scholar
  4. 4.
    C. Y. C. Pak, K. Holt, and J. E. Zerwekh, Invest. Urol. 17:138 (1979).PubMedGoogle Scholar
  5. 5.
    J. M. Goldberg and E. Cotlier, Clin. Chim. Acta 41:19 (1972).PubMedCrossRefGoogle Scholar
  6. 6.
    B. Fellström, U. Backman, B. G. Danielson, K. Holmgren, S. Ljunghall, and B. Wikström, Clin. Sci. 62:509 (1982).PubMedGoogle Scholar
  7. 7.
    F. Kozin and D. J. McCarty, J. Lab. Clin. Med. 89:1314 (1977).PubMedGoogle Scholar
  8. 8.
    T. Koide, M. Takemoto, H. Itatani, M. Takaha, and T. Sonoda, Invest. Urol. 18:382 (1981).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • R. L. Ryall
    • 1
  • R. M. Harnett
    • 1
  • V. R. Marshall
    • 1
  1. 1.Urology Unit, Dept. of SurgeryFlinders Medical CentreBedford ParkAustralia

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