The Relative Inhibitory Potential of Urinary Macromolecular Fractions on Caox Precipitation
One promising approach to increasing the understanding of crystallization inhibitors is to separate the inhibitors and potential promoters from normal healthy urines1. These substances have been found either to promote2 or inhibit CaOx precipitation. In most of the reported studies the accepted approach has been to isolate macromolecular fractions from healthy normal urine and to compare their inhibitory potential with that of similar fractions separated from stone formers’ (SF) urine. The main conclusions from these studies have been: (a) there are no significant differences in the urinary content of inhibitors in SF and normals, (b) some of the fractions isolated from urine may have been damaged by the preparative procedures, and (c) the inhibitory potential in normal urine could not be explained by the inhibition potential of the isolated inhibitors. Thus the inhibitory potential must be due to unknown compounds.
KeywordsInhibitory Potential Stone Former Normal Urine Crystallization Inhibitor Stone Former Urine
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