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Crystal Inhibition:Binding of Heparin and Chondroitin Sulphate to Calcium Oxalate, Sodium Urate and Uric Acid Crystals

  • B. Fellström
  • B. D. Danielson
  • F. A. Karlsson
  • S. Ljunghall

Abstract

Urinary glycosaminoglycans may be important inhibitors of calcium oxalate crystal growth and aggregation1. These inhibitors may act by blocking the growth sites of the crystals and thereby prevent or delay crystal development. Calcium oxalate crystals, that had grown in human urine, have been found to contain chondroitin sulphate2. Furthermore, a solid phase of sodium urate in urine has been suggested to act as an anti-inhibitor by binding urinary glycosaminoglycans and thereby reduce its inhibitory activity against calcium oxalate crystallisation3,4. The binding of heparin to sodium urate crystals was also shown to be enhanced in the presence of divalent cations, such as calcium or magnesium5. We applied the principles used in receptor studies to examine the affinity of two potential inhibitors, heparin and chondroitin sulphate, to calcium oxalate, sodium urate and uric acid crystals.

Keywords

Chondroitin Sulphate Human Urine Calcium Oxalate Calcium Oxalate Crystal Sodium Oxalate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • B. Fellström
    • 1
  • B. D. Danielson
    • 1
  • F. A. Karlsson
    • 1
  • S. Ljunghall
    • 1
  1. 1.Dept. of Internal MedicineUniversity HospitalUppsalaSweden

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