Natural Inhibitors of Formation and Dissolution of Stone Minerals
In assessing the inhibitory activity of urine, seeded COM mineralization experiments are usually made in the presence of high urine dilutions (typically 100-fold) but there is some question as to whether these results can be extrapolated to in vivo conditions1,2. In our laboratory, by using a calcium-specific ion electrode protected from the poisoning effects of urinary macromolecules by means of a dialysis membrane, it is now possible to measure rates of mineralization and demineralization of stone components in whole urines with a precision hitherto unattainable.
KeywordsCalcium Oxalate Calcium Oxalate Stone Total Calcium Concentration Free Ionic Concentration Stone Mineral
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- 2.B. Finlayson, in: “Calcium Metabolism in Renal Failure and Nephrolithiasis”, D. S. David, ed., Wiley, New York (1977).Google Scholar