The Conditions for Precipitation of Uric Acid and Sodium Acid Urate
Anhydrous uric acid (H2U), uric acid dihydrate (H2U.2H2O) and sodium acid urate monohydrate (NaHU.H2O) have been detected in urinary calculi1. A positive relationship between hyperuricosuria and calcium oxalate stone formation has also been demonstrated2. This relationship could be explained by the presence in urine of a microcrystalline or colloidal form of NaHU which might adsorb the known inhibitors of crystal growth and aggregation3or induce epitaxial growth of calcium oxalate crystals4.Data on the precipitation of these solid phases from unseeded solutions are scarce and unsystematic. It would be of considerable interest to work out phase5 and precipitation diagrams6,7 that would show which solid phase may be expected under given experimental conditions. In this paper the systems: H2U-NaOH-HCl-H2O (I) and H2U-Na0H-NaCl-H20, at pH = 7.5 (II) are represented by such diagrams.
KeywordsUric Acid Calcium Oxalate Break Curve Calcium Oxalate Crystal Colloidal Form
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- 1.D. J. Sutor and S. Scheidt, Br. J. Urol. 15:22 (1968).Google Scholar
- 3.W. G. Robertson, F. Knowles, and M. Peacock, in: “Urolithiasis Research”, H. Fleisch, W. G. Robertson, L. H. Smith and W. Vahlensieck, eds., Plenum, New York (1976).Google Scholar
- 5.W. E. Brown, in: “Environmental Phosphorus Handbook”, E. J. Griffiths, A. Beston, J. M. Speer and B. T. Mitchell, eds., John Wiley, New York (1973).Google Scholar
- 6.H. Füredi, in: “The Formation and Properties of Precipitates”, A. G. Walton, ed., Interscience Publishers, New York (1962).Google Scholar
- 7.H. Füredi-Milhofer, Croat. Chem. Acta 56:721 (1983).Google Scholar
- 8.C. Y. Lam, G. H. Nancollas, and S. J. Ko, Invest. Urol. 15:673 (1978).Google Scholar