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Calculation of Complex Chemical Equilibria in Urine: Estimation of the Risk of Stone Formation and Derivation of Prophylactic Measures

  • W. Achilles
  • B. Ulshöfer

Abstract

The degree of supersaturation of a precipitating system is defined as G = -RT ln(AP/Ksp), where AT = the activity product of the precipitating ions and Ksp= the corresponding solubility product. In solutions such as urine containing interacting ligands and metal ions, the AP may be governed by multiple equilibrium reactions. This is the case with calcium oxalate, one of the most important constituents of urinary stones. From the corresponding thermodynamic equilibrium constants, AP can be calculated from the total concentrations of all the ions concerned and the pH of the solution1-4.

Keywords

Stone Formation Calcium Oxalate Urinary Stone Urinary Oxalate Calcium Oxalate Stone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    G. H. Nancollas, “Interactions in Electrolyte Solutions”, Elsevier, Amsterdam (1966).Google Scholar
  2. 2.
    W. G. Robertson, Clin. Chim. Acta 24:149 (1969).PubMedCrossRefGoogle Scholar
  3. 3.
    B. Finlayson and F. Reid, Invest. Urol. 15:442 (1978).PubMedGoogle Scholar
  4. 4.
    W. Achilles, G. A. Cumme, and M. Scheffel, in “Urolithiasis Research”, H. Fleisch, W. G. Robertson, L. H. Smith, and W. Vahlensieck, eds., Plenum, New York (1976).Google Scholar
  5. 5.
    Stability Constants of Metal-Ion Complexes, Part A:Inorganic Ligands, IUPAC Chemical Data Series No. 21 (1980).Google Scholar
  6. 6.
    Stability Constants of Metal-Ion Complexes, Part B:Organic Ligands, IUPAC Chemical Data Series No. 22 (1979).Google Scholar
  7. 7.
    P. G. Koutsoukos, C. Y. Lam-Erwin, and G. H. Nancollas, Invest. Urol. 18:178 (1980).PubMedGoogle Scholar
  8. 8.
    D. D. Perrin and I. G. Sayce, Talanta 14:833 (1967).PubMedCrossRefGoogle Scholar
  9. 9.
    B. Finlayson, R. Roth, and L. DuBois, in: “Urinary Calculi”, L. Cifuentes Delatte, A. Rapado, and A. Hodgkinson, eds., Karger, Basel (1973).Google Scholar
  10. 10.
    P. G. Daniele and M. Marangella, Ann. Chim. 72:25 (1982).Google Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • W. Achilles
    • 1
  • B. Ulshöfer
    • 1
  1. 1.Urologische Universitätsklinik und Poliklinik MarburgMarburgGermany

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