A Whole Urine System for Studying Nucleation, Growth and Aggregation of Calcium Oxalate Crystals
Urinary inhibitors have been presumed for many years to be involved in the pathogenesis of renal calculi. Studies on the effects of dilute urines on calcium oxalate crystallisation have contributed greatly to our knowledge of these inhibitors. Nonetheless, the shortcomings of using diluted urines have always been acknowledged1. The aim of this study was to develop a system for measuring calcium oxalate crystallisation in whole urine and to determine whether or not undiluted urines from stone formers and normal subjects differ either in their ability to resist precipitation or in their response to a given oxalate load.
KeywordsFiltration Oxalate Supersaturation Monohydrate Glycosaminoglycan
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