Urine Supersaturation: the Nucleation, Growth and Dissolution of Stones

  • G. H. Nancollas
Conference paper


It is generally accepted that the formation of stones in the urinary tract involves 4 basic steps: (a) the achievement of solution supersaturation with respect to the mineralizing phase, (b) the formation of stable nidi or nuclei, (c) the development of macrocrystals through crystal growth, aggregation or agglomeration and, (d) the opposing process of dissolution. Elucidation of the controlling mechanisms offers a considerable challenge since the process may result from the failure of natural inhibitors which, in normal subjects, prevent the formation of crystalluria. It is the purpose of this paper to discuss the important factors involved in these processes in relation to an understanding of the mechanisms of stone formation.


Calcium Oxalate Constant Composition Crystallization Experiment Calcium Oxalate Monohydrate Spiral Growth 


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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • G. H. Nancollas
    • 1
  1. 1.Chemistry DeptState University of New YorkBuffaloUSA

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